Caveolin 1

CAV1
Identifiers
Aliases	CAV1, BSCL3, CGL3, LCCNS, MSTP085, PPH3, VIP21, Caveolin 1
External IDs	OMIM: 601047; MGI: 102709; HomoloGene: 1330; GeneCards: CAV1; OMA:CAV1 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	116,561,179 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	17,341,451 bp
RNA expression pattern
	Top expressed in
	lower lobe of lung; ; parietal pleura; ; skin of hip; ; synovial joint; ; visceral pleura; ; adipose tissue; ; subcutaneous adipose tissue; ; right lung; ; vena cava; ; Achilles tendon;
	Top expressed in
	left lung lobe; ; right lung; ; white adipose tissue; ; right lung lobe; ; endothelial cell of lymphatic vessel; ; carotid body; ; belly cord; ; subcutaneous adipose tissue; ; brown adipose tissue; ; atrioventricular valve;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein-macromolecule adaptor activity; transmembrane transporter binding; structural molecule activity; signaling receptor binding; nitric-oxide synthase binding; patched binding; enzyme binding; peptidase activator activity; protein binding; molecular adaptor activity; protein kinase binding; ATPase binding; cholesterol binding; inward rectifier potassium channel inhibitor activity; identical protein binding; protein heterodimerization activity; protein-containing complex binding;
Cellular component	endocytic vesicle membrane; endosome; membrane; focal adhesion; VCP-NPL4-UFD1 AAA ATPase complex; perinuclear region of cytoplasm; caveola; cilium; apical plasma membrane; endoplasmic reticulum; membrane raft; integral component of membrane; Golgi apparatus; early endosome membrane; plasma membrane; intracellular anatomical structure; cell cortex; endoplasmic reticulum membrane; Golgi membrane; integral component of plasma membrane; acrosomal membrane; basolateral plasma membrane; cytoplasmic vesicle; lipid droplet; cytoplasm; protein-containing complex; sarcolemma;
Biological process	caveolin-mediated endocytosis; positive regulation of calcium ion transport into cytosol; vasoconstriction; response to progesterone; negative regulation of protein binding; regulation of peptidase activity; protein localization to plasma membrane raft; mammary gland development; vasculogenesis; negative regulation of pinocytosis; response to ischemia; angiogenesis; apoptotic signaling pathway; positive regulation of extrinsic apoptotic signaling pathway; cholesterol homeostasis; triglyceride metabolic process; negative regulation of canonical Wnt signaling pathway; calcium ion transport; negative regulation of cell population proliferation; cellular response to transforming growth factor beta stimulus; positive regulation of toll-like receptor 3 signaling pathway; regulation of cytosolic calcium ion concentration; regulation of smooth muscle contraction; vesicle organization; negative regulation of peptidyl-tyrosine autophosphorylation; regulation of cardiac muscle cell action potential involved in regulation of contraction; negative regulation of transforming growth factor beta receptor signaling pathway; protein localization to basolateral plasma membrane; receptor internalization involved in canonical Wnt signaling pathway; regulation of membrane repolarization during action potential; positive regulation of peptidyl-serine phosphorylation; negative regulation of protein tyrosine kinase activity; regulation of entry of bacterium into host cell; negative regulation of MAP kinase activity; positive regulation of vasoconstriction; negative regulation of potassium ion transmembrane transport; lactation; receptor-mediated endocytosis of virus by host cell; regulation of blood coagulation; regulation of ventricular cardiac muscle cell action potential; protein homooligomerization; viral process; positive regulation of intrinsic apoptotic signaling pathway; negative regulation of receptor signaling pathway via JAK-STAT; mammary gland involution; calcium ion homeostasis; negative regulation of necroptotic process; regulation of the force of heart contraction; lipid storage; nitric oxide homeostasis; membrane depolarization; negative regulation of cytokine-mediated signaling pathway; cellular calcium ion homeostasis; negative regulation of transcription by RNA polymerase II; response to estrogen; response to calcium ion; regulation of fatty acid metabolic process; cellular response to exogenous dsRNA; negative regulation of MAPK cascade; regulation of ruffle assembly; positive regulation of protein binding; positive regulation of protein ubiquitination; negative regulation of anoikis; leukocyte migration; protein localization; positive regulation of cell adhesion molecule production; response to hypoxia; negative regulation of nitric-oxide synthase activity; response to bacterium; caveola assembly; cellular response to hyperoxia; cholesterol transport; cellular response to starvation; T cell costimulation; regulation of nitric-oxide synthase activity; receptor internalization; positive regulation of peptidase activity; positive regulation of ER-associated ubiquitin-dependent protein catabolic process; negative regulation of endothelial cell proliferation; negative regulation of BMP signaling pathway; negative regulation of protein ubiquitination; cellular response to peptide hormone stimulus; positive regulation of gene expression; negative regulation of nitric oxide biosynthetic process; angiotensin-activated signaling pathway involved in heart process; protein complex oligomerization; negative regulation of peptidyl-serine phosphorylation; posttranscriptional regulation of gene expression; positive regulation of gap junction assembly; maintenance of protein location in cell; negative regulation of signal transduction; regulation of the force of heart contraction by chemical signal; regulation of cell communication by electrical coupling involved in cardiac conduction; regulation of heart rate by cardiac conduction; negative regulation of epithelial cell differentiation; skeletal muscle tissue development; beta-catenin destruction complex disassembly; positive regulation of catalytic activity; positive regulation of canonical Wnt signaling pathway; negative regulation of tyrosine phosphorylation of STAT protein; negative regulation of inward rectifier potassium channel activity; cell differentiation; positive regulation of cell migration; positive regulation of cold-induced thermogenesis; positive regulation of NF-kappaB transcription factor activity;
	Sources:Amigo / QuickGO
Orthologs
	857
	12389
	ENSG00000105974
	ENSMUSG00000007655
	Q03135
	P49817
	NM_001753; NM_001172895; NM_001172896; NM_001172897
	NM_001243064; NM_007616
	NP_001166366; NP_001166367; NP_001166368; NP_001744
	NP_001229993; NP_031642
	Wikidata
View/Edit Human	View/Edit Mouse

Caveolin-1 is a protein that in humans is encoded by the CAV1 gene.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000105974 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000007655 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Fra AM, Mastroianni N, Mancini M, Pasqualetto E, Sitia R (March 1999). "Human caveolin-1 and caveolin-2 are closely linked genes colocalized with WI-5336 in a region of 7q31 frequently deleted in tumors". Genomics. 56 (3): 355–6. doi:10.1006/geno.1998.5723. PMID 10087206.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000105974 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000007655 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10087206-5] Fra AM, Mastroianni N, Mancini M, Pasqualetto E, Sitia R (March 1999). "Human caveolin-1 and caveolin-2 are closely linked genes colocalized with WI-5336 in a region of 7q31 frequently deleted in tumors". Genomics. 56 (3): 355–6. doi:10.1006/geno.1998.5723. PMID 10087206.

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