Cholecystokinin

CCK
Identifiers
Aliases	CCK, cholecystokinin
External IDs	OMIM: 118440; MGI: 88297; HomoloGene: 583; GeneCards: CCK; OMA:CCK - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p22.1 Start 42,257,825 bp[1] End 42,266,185 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 72.43 cM|9 F4 Start 121,318,890 bp[2] End 121,324,760 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in frontal pole Brodmann area 10 orbitofrontal cortex middle temporal gyrus dorsolateral prefrontal cortex cingulate gyrus amygdala Brodmann area 9 superior frontal gyrus Brodmann area 46 Top expressed in primary motor cortex lateral geniculate nucleus Region I of hippocampus proper medial dorsal nucleus superior frontal gyrus entorhinal cortex medial geniculate nucleus prefrontal cortex hippocampus proper subiculum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function hormone activity protein binding neuropeptide hormone activity peptide hormone receptor binding Cellular component perikaryon extracellular region terminal bouton neuronal cell body dendrite axon hillock axon initial segment extracellular space axon Biological process regulation of sensory perception of pain eating behavior behavioral fear response negative regulation of appetite protein kinase C-activating G protein-coupled receptor signaling pathway positive regulation of mitochondrial depolarization positive regulation of glutamate secretion positive regulation of cell population proliferation positive regulation of protein oligomerization positive regulation of peptidyl-tyrosine phosphorylation positive regulation of apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process signal transduction release of cytochrome c from mitochondria apoptotic process neuron migration axonogenesis regulation of signaling receptor activity G protein-coupled receptor signaling pathway memory visual learning negative regulation of eating behavior positive regulation of sensory perception of pain negative regulation of behavioral fear response positive regulation of behavioral fear response digestion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 885 12424 Ensembl ENSG00000187094 ENSMUSG00000032532 UniProt P06307 P09240 RefSeq (mRNA) NM_000729 NM_001174138 NM_031161 NM_001284508 RefSeq (protein) NP_000720 NP_001167609 NP_001271437 NP_112438 Location (UCSC) Chr 3: 42.26 – 42.27 Mb Chr 9: 121.32 – 121.32 Mb PubMed search [3] [4]
Wikidata
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Cholecystokinin (CCK or CCK-PZ; from Greek chole, "bile"; cysto, "sac"; kinin, "move"; hence, move the bile-sac (gallbladder)) is a peptide hormone of the gastrointestinal system responsible for stimulating the digestion of fat and protein. Cholecystokinin, formerly called pancreozymin, is synthesized and secreted by enteroendocrine cells in the duodenum, the first segment of the small intestine. Its presence causes the release of digestive enzymes and bile from the pancreas and gallbladder, respectively, and also acts as a hunger suppressant.^[5][6]