Choline acetyltransferase

CHAT
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2FY2, 2FY3, 2FY4, 2FY5
Identifiers
Aliases	CHAT, CHOACTASE, CMS1A, CMS1A2, CMS6, choline O-acetyltransferase
External IDs	OMIM: 118490; MGI: 88392; HomoloGene: 40693; GeneCards: CHAT; OMA:CHAT - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q11.23 Start 49,609,095 bp[1] End 49,667,942 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14 B|14 19.4 cM Start 32,130,160 bp[2] End 32,187,946 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad testicle putamen mucosa of transverse colon caudate nucleus nucleus accumbens placenta small intestine duodenum appendix Top expressed in facial motor nucleus lumbar subsegment of spinal cord habenula nucleus ambiguus anterior horn of spinal cord striatum of neuraxis central gray substance of midbrain superior frontal gyrus neural layer of retina globus pallidus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity acyltransferase activity choline O-acetyltransferase activity Cellular component cytoplasm cytosol nucleus presynapse neuron projection Biological process neurotransmitter biosynthetic process phosphatidylcholine biosynthetic process neurotransmitter secretion neuromuscular synaptic transmission acetylcholine biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1103 12647 Ensembl ENSG00000070748 ENSMUSG00000021919 UniProt P28329 Q8BQV2 RefSeq (mRNA) NM_020986 NM_001142929 NM_001142933 NM_001142934 NM_020549 NM_020984 NM_020985 NM_009891 RefSeq (protein) NP_001136401 NP_001136405 NP_001136406 NP_065574 NP_066264 NP_066265 NP_066266 NP_034021 Location (UCSC) Chr 10: 49.61 – 49.67 Mb Chr 14: 32.13 – 32.19 Mb PubMed search [3] [4]
Wikidata
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Choline acetyltransferase (commonly abbreviated as ChAT, but sometimes CAT) is a transferase enzyme responsible for the synthesis of the neurotransmitter acetylcholine. ChAT catalyzes the transfer of an acetyl group from the coenzyme acetyl-CoA to choline, yielding acetylcholine (ACh). ChAT is found in high concentration in cholinergic neurons, both in the central nervous system (CNS) and peripheral nervous system (PNS). As with most nerve terminal proteins, ChAT is produced in the body of the neuron and is transported to the nerve terminal, where its concentration is highest. Presence of ChAT in a nerve cell classifies this cell as a "cholinergic" neuron. In humans, the choline acetyltransferase enzyme is encoded by the CHAT gene.^[5]