Chromium(III) picolinate

Chromium(III) picolinate
Ball and Stick model of chromium (III) picolinate	Spacefill model of chromium (III) picolinate
Names
	IUPAC name Tris(picolinate)chromium(III)
Identifiers
CAS Number	14639-25-9 ;
3D model (JSmol)	ionic form: Interactive image; coordination form: Interactive image;
ChEBI	CHEBI:50369 ;
ChemSpider	133913 ;
ECHA InfoCard	100.131.423
PubChem CID	151932;
UNII	S71T8B8Z6P ;
CompTox Dashboard (EPA)	DTXSID1024831 ;
	InChI InChI=1S/3C6H5NO2.Cr/c38-6(9)5-3-1-2-4-7-5;/h31-4H,(H,8,9);/q;;;+3/p-3 Key: CBDQOLKNTOMMTL-UHFFFAOYSA-K ; InChI=1/3C6H5NO2.Cr/c38-6(9)5-3-1-2-4-7-5;/h31-4H,(H,8,9);/q;;;+3/p-3 Key: CBDQOLKNTOMMTL-DFZHHIFOAM;
	SMILES ionic form: c1ccnc(c1)C(=O)[O-].c1ccnc(c1)C(=O)[O-].c1ccnc(c1)C(=O)[O-].[Cr+3]; coordination form: c0ccc[n+]1c0C(=O)O[Cr-3]123(OC(=O)c0[n+]2cccc0)OC(=O)c0[n+]3cccc0;
Properties
Chemical formula	Cr(C6H4NO2)3
Molar mass	418.33 g/mol
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

Chromium(III) picolinate is a chemical compound with the formula Cr(C₅H₄N(CO₂H))₃, commonly abbreviated as CrPic_3. It is sold as a nutritional supplement to treat type 2 diabetes and promote weight loss.^[1] This bright-red coordination compound is derived from chromium(III) and picolinic acid. Trace amounts (25-35 mcg^[2]) of chromium are needed for glucose utilization by insulin in normal health, but deficiency is extremely uncommon and has been observed usually in people receiving 100% of their nutrient needs intravenously, i.e., total parenteral nutrition diets.^[3] Chromium has been identified as regulating insulin by increasing the sensitivity of the insulin receptor.^[4] As such, chromium(III) picolinate has been proposed as a treatment for type 2 diabetes, although its effectiveness remains controversial due to conflicting evidence from human trials.^[5]

^ Preuss, H. G.; Echard, B.; Perricone, N. V.; Bagchi, D.; Yasmin, T.; Stohs, S. J. (2008). "Comparing metabolic effects of six different commercial trivalent chromium compounds". Journal of Inorganic Biochemistry. 102 (11): 1986–1990. doi:10.1016/j.jinorgbio.2008.07.012. PMID 18774175.
^ "The Nutrition Source: Chromium". School of Public Health, Harvard University.
^ Review of Chromium Archived February 7, 2012, at the Wayback Machine Expert Group on Vitamins and Minerals Review of Chromium, 12 August 2002
^ Stearns DM (2000). "Is chromium a trace essential metal?". BioFactors. 11 (3): 149–62. doi:10.1002/biof.5520110301. PMID 10875302. S2CID 19417496.
^ Vincent, John (2010). "Chromium: celebrating 50 years as an essential element?". Dalton Transactions. 39 (16): 3787–3794. doi:10.1039/B920480F. PMID 20372701.

[1] Preuss, H. G.; Echard, B.; Perricone, N. V.; Bagchi, D.; Yasmin, T.; Stohs, S. J. (2008). "Comparing metabolic effects of six different commercial trivalent chromium compounds". Journal of Inorganic Biochemistry. 102 (11): 1986–1990. doi:10.1016/j.jinorgbio.2008.07.012. PMID 18774175.

[2] "The Nutrition Source: Chromium". School of Public Health, Harvard University.

[3] Review of Chromium Archived February 7, 2012, at the Wayback Machine Expert Group on Vitamins and Minerals Review of Chromium, 12 August 2002

[4] Stearns DM (2000). "Is chromium a trace essential metal?". BioFactors. 11 (3): 149–62. doi:10.1002/biof.5520110301. PMID 10875302. S2CID 19417496.

[Cr50yr-5] Vincent, John (2010). "Chromium: celebrating 50 years as an essential element?". Dalton Transactions. 39 (16): 3787–3794. doi:10.1039/B920480F. PMID 20372701.

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