Complement receptor

A complement receptor is a membrane-bound receptor belonging to the complement system, which is part of the innate immune system. Complement receptors bind effector protein fragments that are produced in response to antigen-antibody complexes or damage-associated molecules.^[1] Complement receptor activation contributes to the regulation of inflammation, leukocyte extravasation, and phagocytosis; it also contributes to the adaptive immune response.^[2]^[3] Different complement receptors can participate in either the classical complement pathway, the alternative complement pathway, or both.^[4]

^ Holers VM (29 January 2014). "Complement and its receptors: new insights into human disease". Annual Review of Immunology. 32: 433–59. doi:10.1146/annurev-immunol-032713-120154. PMID 24499275.
^ Verschoor A, Kemper C, Köhl J (15 September 2017). "Complement Receptors". eLS: 1–17. doi:10.1002/9780470015902.a0000512.pub3. ISBN 9780470015902.
^ Carroll MC (December 2008). "Complement and humoral immunity". Vaccine. 26 (Suppl 8): I28-33. doi:10.1016/j.vaccine.2008.11.022. PMC 4018718. PMID 19388161.
^ Janeway Jr CA, Travers P, Walport M, Shlomchik MJ (2001). "The complement system and innate immunity". Immunobiology: The Immune System in Health and Disease (5th ed.). New York: Garland Science. Retrieved 17 June 2020.