Complex traits

Complex traits are phenotypes that are controlled by two or more genes and do not follow Mendel’s Law of Dominance. They may have a range of expression which is typically continuous. Both environmental and genetic factors often impact the variation in expression. Human height is a continuous trait meaning that there is a wide range of heights. There are an estimated 50 genes that affect the height of a human. Environmental factors, like nutrition, also play a role in a human’s height. Other examples of complex traits include: crop yield, plant color, and many diseases including diabetes and Parkinson's disease. One major goal of genetic research today is to better understand the molecular mechanisms through which genetic variants act to influence complex traits. Complex Traits are also known as polygenic traits and multigenic traits. ^[1][2]

The existence of complex traits, which are far more common than Mendelian traits, represented a significant challenge to the acceptance of Mendel’s work. Modern understanding has 3 categories of complex traits: quantitative, meristic, and threshold. These traits have been studied on a small scale with observational techniques like twin studies. They are also studied with statistical techniques like quantitative trait loci(QTL) mapping, and genome-wide association studies(GWAS) on a large scale. The overall goal of figuring out how genes interact with each other and the environment and how those interactions can lead to variation in a trait is called genetic architecture.