COX1 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
Aliases | COX1, mitochondrially encoded cytochrome c oxidase I, COI, MTCO1, Main subunit of cytochrome c oxidase, CO I, cytochrome c oxidase subunit I | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 516030; MGI: 102504; HomoloGene: 5016; GeneCards: COX1; OMA:COX1 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Cytochrome c oxidase subunit I | |||||||||
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![]() Structure of the 13-subunit oxidized cytochrome c oxidase.[5] | |||||||||
Identifiers | |||||||||
Symbol | COX1 or COI | ||||||||
Pfam | PF00115 | ||||||||
InterPro | IPR000883 | ||||||||
PROSITE | PDOC00074 | ||||||||
SCOP2 | 1occ / SCOPe / SUPFAM | ||||||||
TCDB | 3.D.4 | ||||||||
OPM superfamily | 4 | ||||||||
OPM protein | 1v55 | ||||||||
CDD | cd01663 | ||||||||
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Cytochrome c oxidase I (COX1) also known as mitochondrially encoded cytochrome c oxidase I (MT-CO1) is a protein that is encoded by the MT-CO1 gene in eukaryotes.[6] The gene is also called COX1, CO1, or COI.[7] Cytochrome c oxidase I is the main subunit of the cytochrome c oxidase complex. In humans, mutations in MT-CO1 have been associated with Leber's hereditary optic neuropathy (LHON), acquired idiopathic sideroblastic anemia, Complex IV deficiency, colorectal cancer, sensorineural deafness, and recurrent myoglobinuria.[8][9][10]
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