DNA-PKcs

PRKDC
Identifiers
Aliases	PRKDC, DNA-PKcs, DNAPK, DNPK1, HYRC, HYRC1, XRCC7, p350, IMD26, protein kinase, DNA-activated, catalytic polypeptide, DNA-PKC, protein kinase, DNA-activated, catalytic subunit, DNAPKc
External IDs	OMIM: 600899; MGI: 104779; HomoloGene: 5037; GeneCards: PRKDC; OMA:PRKDC - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	47,960,178 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	15,660,099 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; stromal cell of endometrium; ; ganglionic eminence; ; epithelium of colon; ; oral cavity; ; left uterine tube; ; ectocervix; ; right ovary; ; testicle; ; human penis;
	Top expressed in
	olfactory tubercle; ; saccule; ; medullary collecting duct; ; Paneth cell; ; cornea; ; epithelium of lens; ; lacrimal gland; ; hair follicle; ; nucleus accumbens; ; ureter;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; nucleotide binding; DNA binding; DNA-dependent protein kinase activity; transcription factor binding; kinase activity; protein serine/threonine kinase activity; protein binding; enzyme binding; ATP binding; RNA binding; double-stranded DNA binding; protein kinase activity; protein domain specific binding;
Cellular component	cytosol; membrane; transcription regulator complex; nucleoplasm; DNA-dependent protein kinase-DNA ligase 4 complex; nonhomologous end joining complex; extracellular matrix; nucleus; protein-DNA complex; nucleolus; protein-containing complex;
Biological process	somitogenesis; negative regulation of protein phosphorylation; response to ionizing radiation; negative regulation of response to gamma radiation; positive regulation of immune system process; DNA recombination; positive regulation of developmental growth; T cell differentiation in thymus; telomere capping; phosphorylation; rhythmic process; thymus development; positive regulation of fibroblast proliferation; lymphocyte differentiation; T cell receptor V(D)J recombination; negative regulation of apoptotic process; double-strand break repair via alternative nonhomologous end joining; spleen development; negative regulation of immunoglobulin production; response to activity; regulation of smooth muscle cell proliferation; cellular response to DNA damage stimulus; heart development; pro-B cell differentiation; brain development; B cell lineage commitment; peptidyl-serine phosphorylation; protein destabilization; regulation of circadian rhythm; intrinsic apoptotic signaling pathway in response to DNA damage; V(D)J recombination; cellular response to insulin stimulus; positive regulation of apoptotic process; ectopic germ cell programmed cell death; immunoglobulin V(D)J recombination; cell population proliferation; double-strand break repair via nonhomologous end joining; telomere maintenance; response to gamma radiation; positive regulation of type I interferon production; T cell lineage commitment; positive regulation of transcription by RNA polymerase II; negative regulation of cellular senescence; immunoglobulin production; double-strand break repair; DNA repair; protein ubiquitination; protein phosphorylation; activation of innate immune response; immune system process; innate immune response; regulation of epithelial cell proliferation; positive regulation of double-strand break repair via nonhomologous end joining;
	Sources:Amigo / QuickGO
Orthologs
	5591
	19090
	ENSG00000253729
	ENSMUSG00000022672
	P78527
	P97313
	NM_001081640; NM_006904
	NM_011159
	NP_001075109; NP_008835
	NP_035289
	Wikidata
View/Edit Human	View/Edit Mouse

DNA-dependent protein kinase, catalytic subunit, also known as DNA-PKcs, is an enzyme that in humans is encoded by the gene designated as PRKDC or XRCC7.^[5] DNA-PKcs belongs to the phosphatidylinositol 3-kinase-related kinase protein family. The DNA-Pkcs protein is a serine/threonine protein kinase consisting of a single polypeptide chain of 4,128 amino acids.^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000253729 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022672 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Sipley JD, Menninger JC, Hartley KO, Ward DC, Jackson SP, Anderson CW (August 1995). "Gene for the catalytic subunit of the human DNA-activated protein kinase maps to the site of the XRCC7 gene on chromosome 8". Proceedings of the National Academy of Sciences of the United States of America. 92 (16): 7515–7519. Bibcode:1995PNAS...92.7515S. doi:10.1073/pnas.92.16.7515. PMC 41370. PMID 7638222.
^ Sibanda BL, Chirgadze DY, Blundell TL (January 2010). "Crystal structure of DNA-PKcs reveals a large open-ring cradle comprised of HEAT repeats". Nature. 463 (7277): 118–121. doi:10.1038/nature08648. PMC 2811870. PMID 20023628.
^ Hartley KO, Gell D, Smith GC, Zhang H, Divecha N, Connelly MA, et al. (September 1995). "DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product". Cell. 82 (5): 849–856. doi:10.1016/0092-8674(95)90482-4. PMID 7671312.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000253729 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022672 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7638222-5] Sipley JD, Menninger JC, Hartley KO, Ward DC, Jackson SP, Anderson CW (August 1995). "Gene for the catalytic subunit of the human DNA-activated protein kinase maps to the site of the XRCC7 gene on chromosome 8". Proceedings of the National Academy of Sciences of the United States of America. 92 (16): 7515–7519. Bibcode:1995PNAS...92.7515S. doi:10.1073/pnas.92.16.7515. PMC 41370. PMID 7638222.

[pmid20023628-6] Sibanda BL, Chirgadze DY, Blundell TL (January 2010). "Crystal structure of DNA-PKcs reveals a large open-ring cradle comprised of HEAT repeats". Nature. 463 (7277): 118–121. doi:10.1038/nature08648. PMC 2811870. PMID 20023628.

[pmid7671312-7] Hartley KO, Gell D, Smith GC, Zhang H, Divecha N, Connelly MA, et al. (September 1995). "DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product". Cell. 82 (5): 849–856. doi:10.1016/0092-8674(95)90482-4. PMID 7671312.

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