Dimenhydrinate

Dimenhydrinate
Combination of
Diphenhydramine	Antihistamine, sedative
8-chlorotheophylline	Stimulant
Clinical data
Trade names	Dramamine, Draminate, Gravol, others
AHFS/Drugs.com	Monograph
MedlinePlus	a607046
License data	US DailyMed: Dimenhydrinate;
Pregnancy; category	AU: A; ;
Routes of; administration	By mouth, rectal, intravascular, intramuscular
ATC code	R06AA11 (WHO) combinations R06AA61 (WHO);
Legal status
Legal status	AU: S2 (Pharmacy medicine); CA: OTC; US: OTC;
Pharmacokinetic data
Metabolism	Liver
Elimination half-life	5.5 hours (diphenhydramine component)
Identifiers
CAS Number	523-87-5 ;
PubChem CID	10660;
DrugBank	DB00985 ;
ChemSpider	10210 ;
UNII	JB937PER5C;
KEGG	D00520 ;
ChEBI	CHEBI:94848;
ChEMBL	ChEMBL1200406 ;
CompTox Dashboard (EPA)	DTXSID9025087 ;
ECHA InfoCard	100.007.593
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Dimenhydrinate, sold under the brand name Dramamine, among others, is an over-the-counter medication used to treat motion sickness and nausea. Dimenhydrinate is a theoclate salt composed of diphenhydramine (an ethanolamine derivative) and 8-chlorotheophylline (a chlorinated theophylline derivative) in a 1:1 ratio.^[2]

Dimenhydrinate was introduced to the market by G.D. Searle in 1949.^[3]^[4]

^ Scavone JM, Luna BG, Harmatz JS, von Moltke L, Greenblatt DJ (April 1990). "Diphenhydramine kinetics following intravenous, oral, and sublingual dimenhydrinate administration". Biopharmaceutics & Drug Disposition. 11 (3): 185–189. doi:10.1002/bdd.2510110302. PMID 2328304.
^ Zabirowicz ES, Gan TJ (2019). "34 - Pharmacology of Postoperative Nausea and Vomiting". In Hemmings Jr HC, Talmage ED (eds.). Pharmacology and Physiology for Anesthesia (Second ed.). Elsevier Inc. pp. 671–692. doi:10.1016/B978-0-323-48110-6.00034-X. ISBN 978-0-323-48110-6. S2CID 81387334.
^ Newman A (21 June 2012). "New Dramamine Ads Take Aim at Summer Vacationers". The New York Times. Retrieved 26 June 2023.
^ Grauer N (12 February 2019). "Hopkins History Moments: Neil A. Grauer explains how Hopkins expertise helped prevent seasickness". Johns Hopkins Medicine. Retrieved 27 June 2023.