The discovery of an orally inactive peptide from snake venom established the important role of angiotensin converting enzyme (ACE) inhibitors in regulating blood pressure. This led to the development of captopril, the first ACE inhibitor. When the adverse effects of captopril became apparent new derivates were designed. Then after the discovery of two active sites of ACE: N-domain and C-domain, the development of domain-specific ACE inhibitors began.[1][2]
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- ^ Redelinghuys, P.; Nchinda, A. T.; Sturrock, E. D. (2005), "Development of Domain-Selective Enzyme Inhibitors", Annals of the New York Academy of Sciences, 1056: 160–175, doi:10.1196/annals.1352.035, PMID 16387685, S2CID 25407204
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