Droperidol

Droperidol
Clinical data
Pronunciation	/droʊˈpɛrIdɔːl/
Pregnancy; category	AU: C; ;
Routes of; administration	Intravenous, Intramuscular
Drug class	Typical antipsychotic
ATC code	N05AD08 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only); BR: Class C1 (Other controlled substances); UK: POM (Prescription only); US: WARNINGRx-only;
Pharmacokinetic data
Metabolism	Hepatic
Elimination half-life	2.3 hours
Identifiers
	IUPAC name 3-[1-[4-(4-fluorophenyl)-4-oxobutyl]-3,6-dihydro-2H-pyridin-4-yl]-1H-benzimidazol-2-one;
CAS Number	548-73-2;
PubChem CID	3168;
DrugBank	DB00450;
ChemSpider	3056;
UNII	O9U0F09D5X;
KEGG	D00308;
ChEMBL	ChEMBL1108 ;
CompTox Dashboard (EPA)	DTXSID6022973 ;
ECHA InfoCard	100.008.144
Chemical and physical data
Formula	C22H22FN3O2
Molar mass	379.435 g·mol−1
3D model (JSmol)	Interactive image; Interactive image;
	SMILES c1ccc2c(c1)nc(n2C3=CCN(CC3)CCCC(=O)c4ccc(cc4)F)O; ; Fc1ccc(cc1)C(=O)CCCN2CC=C(CC2)N3c4ccccc4NC3=O;
	InChI InChI=1S/C22H22FN3O2/c23-17-9-7-16(8-10-17)21(27)6-3-13-25-14-11-18(12-15-25)26-20-5-2-1-4-19(20)24-22(26)28/h1-2,4-5,7-11H,3,6,12-15H2,(H,24,28); Key:RMEDXOLNCUSCGS-UHFFFAOYSA-N;

Droperidol /droʊˈpɛrɪdɔːl/ (Inapsine, Droleptan, Dridol, Xomolix, Innovar [combination with fentanyl]) is an antidopaminergic drug used as an antiemetic (that is, to prevent or treat nausea) and as an antipsychotic. Droperidol is also often used as a rapid sedative in intensive-care treatment, and where "agitation aggression or violent behavior"^[4] are present.^[5]^[6]

^ "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 Oct 2023.
^ "Prescription medicines: registration of new generic medicines and biosimilar medicines, 2017". Therapeutic Goods Administration (TGA). 21 June 2022. Retrieved 30 March 2024.
^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
^ Edge R, Argáez C. Droperidol for Agitation in Acute Care [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2021 Jan. Available from: https://www.ncbi.nlm.nih.gov/books/NBK571530/
^ Perkins J, Ho JD, Vilke GM, DeMers G (July 2015). "American Academy of Emergency Medicine Position Statement: Safety of Droperidol Use in the Emergency Department". The Journal of Emergency Medicine. 49 (1): 91–97. doi:10.1016/j.jemermed.2014.12.024. PMID 25837231.
^ Klein LR, Driver BE, Horton G, Scharber S, Martel ML, Cole JB (May 2019). "Rescue Sedation When Treating Acute Agitation in the Emergency Department With Intramuscular Antipsychotics". The Journal of Emergency Medicine. 56 (5): 484–490. doi:10.1016/j.jemermed.2018.12.036. PMID 30745194. S2CID 73436531.

[FDA-AllBoxedWarnings-1] "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 Oct 2023.

[2] "Prescription medicines: registration of new generic medicines and biosimilar medicines, 2017". Therapeutic Goods Administration (TGA). 21 June 2022. Retrieved 30 March 2024.

[3] Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.

[4] Edge R, Argáez C. Droperidol for Agitation in Acute Care [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2021 Jan. Available from: https://www.ncbi.nlm.nih.gov/books/NBK571530/

[5] Perkins J, Ho JD, Vilke GM, DeMers G (July 2015). "American Academy of Emergency Medicine Position Statement: Safety of Droperidol Use in the Emergency Department". The Journal of Emergency Medicine. 49 (1): 91–97. doi:10.1016/j.jemermed.2014.12.024. PMID 25837231.

[6] Klein LR, Driver BE, Horton G, Scharber S, Martel ML, Cole JB (May 2019). "Rescue Sedation When Treating Acute Agitation in the Emergency Department With Intramuscular Antipsychotics". The Journal of Emergency Medicine. 56 (5): 484–490. doi:10.1016/j.jemermed.2018.12.036. PMID 30745194. S2CID 73436531.

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Clinical data


Pronunciation	/droʊˈpɛrIdɔːl/
Pregnancy category	AU: C
Routes of administration	Intravenous, Intramuscular
Drug class	Typical antipsychotic
ATC code	N05AD08 (WHO)
Legal status
Legal status	AU: S4 (Prescription only)^[2] BR: Class C1 (Other controlled substances)^[3] UK: POM (Prescription only) US: WARNING^[1]Rx-only
Pharmacokinetic data
Metabolism	Hepatic
Elimination half-life	2.3 hours
Identifiers
IUPAC name 3-[1-[4-(4-fluorophenyl)-4-oxobutyl]-3,6-dihydro-2H-pyridin-4-yl]-1H-benzimidazol-2-one
CAS Number	548-73-2
PubChem CID	3168
DrugBank	DB00450
ChemSpider	3056
UNII	O9U0F09D5X
KEGG	D00308
ChEMBL	ChEMBL1108^Y
CompTox Dashboard (EPA)	DTXSID6022973
ECHA InfoCard	100.008.144
Chemical and physical data
Formula	C₂₂H₂₂FN₃O₂
Molar mass	379.435 g·mol⁻¹
3D model (JSmol)	Interactive image Interactive image
SMILES c1ccc2c(c1)nc(n2C3=CCN(CC3)CCCC(=O)c4ccc(cc4)F)O Fc1ccc(cc1)C(=O)CCCN2CC=C(CC2)N3c4ccccc4NC3=O
InChI InChI=1S/C22H22FN3O2/c23-17-9-7-16(8-10-17)21(27)6-3-13-25-14-11-18(12-15-25)26-20-5-2-1-4-19(20)24-22(26)28/h1-2,4-5,7-11H,3,6,12-15H2,(H,24,28) Key:RMEDXOLNCUSCGS-UHFFFAOYSA-N