Drosophila connectome

A Drosophila connectome is a list of neurons in the Drosophila melanogaster (fruit fly) nervous system, and the chemical synapses between them. The fly's nervous system consists of the brain plus the ventral nerve cord, and both are known to differ considerably between male and female.[1][2] Dense connectomes have been completed for the female adult brain,[3] the male nerve cord,[4] and the female larval stage.[5] The available connectomes show only chemical synapses - other forms of inter-neuron communication such as gap junctions or neuromodulators are not represented. Drosophila is the most complex creature with a connectome, which had only been previously obtained for three other simpler organisms, first C. elegans.[citation needed] The connectomes have been obtained by the methods of neural circuit reconstruction, which over the course of many years worked up through various subsets of the fly brain to the almost full connectomes that exist today.[citation needed]

  1. ^ Cachero, Sebastian, Aaron D. Ostrovsky, Y. Yu Jai, Barry J. Dickson, and Gregory SXE Jefferis (2010). "Sexual dimorphism in the fly brain" (PDF). Current Biology. 20 (18): 1589–1601. doi:10.1016/j.cub.2010.07.045. PMC 2957842. PMID 20832311. S2CID 14207042.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  2. ^ Kelley, Darcy B.; Bayer, Emily A. (March 22, 2021). "Sexual dimorphism: Neural circuit switches in the Drosophila brain". Current Biology. 31 (6): R297–R298. doi:10.1016/j.cub.2021.02.026. PMID 33756143. S2CID 232314832.
  3. ^ "CODEX: Connectome Data Explorer". Princeton Neuroscience Institute., as described in non-peer-reviewed preprint Dorkenwald S, Matsliah A, Sterling AR, Schlegel P, Yu SC, McKellar CE, et al. (June 2023). "Neuronal wiring diagram of an adult brain". bioRxiv 10.1101/2023.06.27.546656.
  4. ^ "Analysis tools for Connectomics". Janelia Research Campus, HHMI., as described in non-peer-reviewed preprint Takemura SY, Hayworth KJ, Huang GB, Januszewski M, Lu Z, Marin EC, et al. (June 2023). "A Connectome of the Male Drosophila Ventral Nerve Cord". bioRxiv 10.1101/2023.06.05.543757.
  5. ^ Cite error: The named reference Winding_2023 was invoked but never defined (see the help page).

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