EMR1

ADGRE1
Identifiers
Aliases	ADGRE1, TM7LN3, EMR1, adhesion G protein-coupled receptor E1
External IDs	OMIM: 600493; MGI: 106912; HomoloGene: 1493; GeneCards: ADGRE1; OMA:ADGRE1 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	6,940,459 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	57,790,527 bp
RNA expression pattern
	Top expressed in
	monocyte; ; blood; ; granulocyte; ; testicle; ; spleen; ; bone marrow; ; appendix; ; right lung; ; bone marrow cells; ; palpebral conjunctiva;
	Top expressed in
	stroma of bone marrow; ; muscle layer of urethra; ; calvaria; ; granulocyte; ; mesenteric lymph nodes; ; lamina propria of urethra; ; spleen; ; right ventricle; ; tibiofemoral joint; ; ankle joint;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; G protein-coupled receptor activity; transmembrane signaling receptor activity; signal transducer activity;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; membrane; external side of plasma membrane; cell periphery; intracellular anatomical structure;
Biological process	G protein-coupled receptor signaling pathway; cell surface receptor signaling pathway; cell adhesion; adaptive immune response; signal transduction; immune system process; adenylate cyclase-activating G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	2015
	13733
	ENSG00000174837
	ENSMUSG00000004730
	Q14246
	Q61549
	NM_001256252; NM_001256253; NM_001256254; NM_001256255; NM_001974
	NM_010130; NM_001355722; NM_001355723
	NP_001243181; NP_001243182; NP_001243183; NP_001243184; NP_001965
	NP_034260; NP_001342651; NP_001342652
	Wikidata
View/Edit Human	View/Edit Mouse

EGF-like module-containing mucin-like hormone receptor-like 1 also known as F4/80 is a protein encoded by the ADGRE1 gene.^[5]^[6]^[7]^[8]^[9]

EMR1 is a member of the adhesion GPCR family^[10]^[11] characterized by an extended extracellular region containing EGF-like domains. EMR1 is predominantly expressed on the surface of macrophages and plays a significant role in immune response modulation and inflammation. Its expression has been linked to various inflammatory diseases.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000174837 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000004730 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Baud V, Chissoe SL, Viegas-Péquignot E, Diriong S, N'Guyen VC, Roe BA, et al. (March 1995). "EMR1, an unusual member in the family of hormone receptors with seven transmembrane segments". Genomics. 26 (2): 334–344. doi:10.1016/0888-7543(95)80218-B. PMID 7601460.
^ McKnight AJ, Gordon S (March 1998). "The EGF-TM7 family: unusual structures at the leukocyte surface". Journal of Leukocyte Biology. 63 (3): 271–280. doi:10.1002/jlb.63.3.271. PMID 9500513. S2CID 6497890.
^ "Entrez Gene: EMR1 egf-like module containing, mucin-like, hormone receptor-like 1".
^ Leenen PJ, de Bruijn MF, Voerman JS, Campbell PA, van Ewijk W (September 1994). "Markers of mouse macrophage development detected by monoclonal antibodies". Journal of Immunological Methods. 174 (1–2): 5–19. doi:10.1016/0022-1759(94)90005-1. hdl:1765/71089. PMID 8083537.
^ Hamann J, Aust G, Araç D, Engel FB, Formstone C, Fredriksson R, et al. (April 2015). "International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors". Pharmacological Reviews. 67 (2): 338–367. doi:10.1124/pr.114.009647. PMC 4394687. PMID 25713288.
^ Stacey M, Yona S (2011). Adhesion-GPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 978-1-4419-7912-4.
^ Langenhan T, Aust G, Hamann J (May 2013). "Sticky signaling--adhesion class G protein-coupled receptors take the stage". Science Signaling. 6 (276): re3. doi:10.1126/scisignal.2003825. PMID 23695165. S2CID 6958640.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000174837 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000004730 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7601460-5] Baud V, Chissoe SL, Viegas-Péquignot E, Diriong S, N'Guyen VC, Roe BA, et al. (March 1995). "EMR1, an unusual member in the family of hormone receptors with seven transmembrane segments". Genomics. 26 (2): 334–344. doi:10.1016/0888-7543(95)80218-B. PMID 7601460.

[pmid9500513-6] McKnight AJ, Gordon S (March 1998). "The EGF-TM7 family: unusual structures at the leukocyte surface". Journal of Leukocyte Biology. 63 (3): 271–280. doi:10.1002/jlb.63.3.271. PMID 9500513. S2CID 6497890.

[entrez-7] "Entrez Gene: EMR1 egf-like module containing, mucin-like, hormone receptor-like 1".

[pmid8083537-8] Leenen PJ, de Bruijn MF, Voerman JS, Campbell PA, van Ewijk W (September 1994). "Markers of mouse macrophage development detected by monoclonal antibodies". Journal of Immunological Methods. 174 (1–2): 5–19. doi:10.1016/0022-1759(94)90005-1. hdl:1765/71089. PMID 8083537.

[9] Hamann J, Aust G, Araç D, Engel FB, Formstone C, Fredriksson R, et al. (April 2015). "International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors". Pharmacological Reviews. 67 (2): 338–367. doi:10.1124/pr.114.009647. PMC 4394687. PMID 25713288.

[isbn1-4419-7912-3-10] Stacey M, Yona S (2011). Adhesion-GPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 978-1-4419-7912-4.

[11] Langenhan T, Aust G, Hamann J (May 2013). "Sticky signaling--adhesion class G protein-coupled receptors take the stage". Science Signaling. 6 (276): re3. doi:10.1126/scisignal.2003825. PMID 23695165. S2CID 6958640.

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