EN1 (gene)

EN1
Identifiers
Aliases	EN1, engrailed homeobox 1, ENDOVESLB
External IDs	OMIM: 131290 MGI: 95389 HomoloGene: 50663 GeneCards: EN1
Gene location (Human)
Chr.	Chromosome 2 (human)
End	118,847,648 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	120,535,721 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; skin of abdomen; ; biceps brachii; ; quadriceps femoris muscle; ; vastus lateralis muscle; ; skeletal muscle tissue; ; subcutaneous adipose tissue; ; deltoid muscle; ; lymph node; ; tibialis anterior muscle;
	Top expressed in
	sclerotome; ; surface ectoderm; ; rhombic lip; ; ventral tegmental area; ; pharynx; ; interpeduncular nucleus; ; substantia nigra; ; calvaria; ; inferior colliculus; ; footplate;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; sequence-specific DNA binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus; RSC-type complex;
Biological process	negative regulation of neuron apoptotic process; skeletal system development; dopaminergic neuron differentiation; proximal/distal pattern formation; regulation of transcription, DNA-templated; multicellular organism growth; adult locomotory behavior; anatomical structure morphogenesis; hindbrain development; neuron development; negative regulation of transcription by RNA polymerase II; cerebellum development; limb development; multicellular organism development; motor learning; midbrain-hindbrain boundary development; embryonic brain development; drinking behavior; embryonic limb morphogenesis; neuron differentiation; regulation of gene expression; social behavior; pigmentation; dorsal/ventral pattern formation; embryonic forelimb morphogenesis; midbrain development; positive regulation of transcription by RNA polymerase II; negative regulation of neuron death; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	2019
	13798
	ENSG00000163064
	ENSMUSG00000058665
	Q05925
	P09065
	NM_001426
	NM_010133
	NP_001417
	NP_034263
	Wikidata
View/Edit Human	View/Edit Mouse

Homeobox protein engrailed-1 is a protein that in humans is encoded by the EN1 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000163064 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000058665 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kohler A, Logan C, Joyner AL, Muenke M (Mar 1993). "Regional assignment of the human homeobox-containing gene EN1 to chromosome 2q13-q21". Genomics. 15 (1): 233–235. doi:10.1006/geno.1993.1045. PMID 8094370.
^ "Entrez Gene: EN1 engrailed homeobox 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000163064 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000058665 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8094370-5] Kohler A, Logan C, Joyner AL, Muenke M (Mar 1993). "Regional assignment of the human homeobox-containing gene EN1 to chromosome 2q13-q21". Genomics. 15 (1): 233–235. doi:10.1006/geno.1993.1045. PMID 8094370.

[entrez-6] "Entrez Gene: EN1 engrailed homeobox 1".

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