ENO3

ENO3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2XSX
Identifiers
Aliases	ENO3, GSD13, MSE, enolase 3
External IDs	OMIM: 131370; MGI: 95395; HomoloGene: 68215; GeneCards: ENO3; OMA:ENO3 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17p13.2 Start 4,948,092 bp[1] End 4,957,131 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 B3|11 43.21 cM Start 70,548,028 bp[2] End 70,553,339 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Skeletal muscle tissue of rectus abdominis biceps brachii Skeletal muscle tissue of biceps brachii muscle of thigh triceps brachii muscle glutes thoracic diaphragm apex of heart body of tongue gastrocnemius muscle Top expressed in sternocleidomastoid muscle triceps brachii muscle temporal muscle digastric muscle vastus lateralis muscle tibialis anterior muscle ankle gastrocnemius muscle medial head of gastrocnemius muscle extensor digitorum longus muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphopyruvate hydratase activity metal ion binding lyase activity magnesium ion binding protein homodimerization activity protein heterodimerization activity Cellular component plasma membrane phosphopyruvate hydratase complex extracellular exosome extracellular space cytoplasm cytosol membrane Biological process gluconeogenesis glycolytic process canonical glycolysis human ageing skeletal muscle tissue regeneration substantia nigra development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2027 13808 Ensembl ENSG00000108515 ENSMUSG00000060600 UniProt P13929 P21550 RefSeq (mRNA) NM_001193503 NM_001976 NM_053013 NM_001374523 NM_001374524 NM_001136062 NM_001276285 NM_007933 RefSeq (protein) NP_001180432 NP_001967 NP_443739 NP_001361452 NP_001361453 NP_001129534 NP_001263214 NP_031959 Location (UCSC) Chr 17: 4.95 – 4.96 Mb Chr 11: 70.55 – 70.55 Mb PubMed search [3] [4]
Wikidata
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Enolase 3 (ENO3), more commonly known as beta-enolase (ENO-β), is an enzyme that in humans is encoded by the ENO3 gene.

This gene encodes one of the three enolase isoenzymes found in mammals. This isoenzyme is found in skeletal muscle cells in the adult where it may play a role in muscle development and regeneration. A switch from alpha enolase to beta enolase occurs in muscle tissue during development in rodents. Mutations in this gene have been associated with glycogen storage disease. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Jul 2010]^[5]