ER-X is a membrane-associated receptor that is bound and activated by 17α-estradiol and 17β-estradiol and is a putative membrane estrogen receptor (mER).[1][2][3] It shows sequence homology with ERα and ERβ and activates the MAPK/ERK pathway.[3] The receptor is insensitive to the antiestrogen ICI-182,780 (fulvestrant).[3]
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