| Endothelial stem cell | |
|---|---|
 CD34+ endothelial cell among a population of bovine aortic endothelial cells | |
| Details | |
| Location | Bone marrow |
| Identifiers | |
| Latin | cellula endothelialis praecursoria |
| TH | H2.00.01.0.00003 |
| Anatomical terms of microanatomy | |
Endothelial stem cells (ESCs) are one of three types of stem cells found in bone marrow. They are multipotent, which describes the ability to give rise to many cell types, whereas a pluripotent stem cell can give rise to all types. ESCs have the characteristic properties of a stem cell: self-renewal and differentiation. These parent stem cells, ESCs, give rise to progenitor cells, which are intermediate stem cells that lose potency. Progenitor stem cells are committed to differentiating along a particular cell developmental pathway. ESCs will eventually produce endothelial cells (ECs), which create the thin-walled endothelium that lines the inner surface of blood vessels and lymphatic vessels.[1] The blood vessels include arteries and veins. Endothelial cells can be found throughout the whole vascular system and they also play a vital role in the movement of white blood cells[2]
- ^ Fang S, Wei J, Pentinmikko N, Leinonen H, Salven P (16 October 2012). Goodell MA (ed.). "Generation of functional blood vessels from a single c-kit+ adult vascular endothelial stem cell". PLOS Biology. 10 (10): e1001407. doi:10.1371/journal.pbio.1001407. PMC 3473016. PMID 23091420.
- ^ Alberts, Bruce; Johnson, Alexander; Lewis, Julian; Raff, Martin; Roberts, Keith; Walter, Peter (2002). "Blood Vessels and Endothelial Cells". Molecular Biology of the Cell. 4th Edition.
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