Estrogen receptor beta

ESR2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4J26, 1L2J, 1NDE, 1QKM, 1U3Q, 1U3R, 1U3S, 1U9E, 1X76, 1X78, 1X7B, 1X7J, 1YY4, 1YYE, 1ZAF, 2FSZ, 2GIU, 2I0G, 2JJ3, 2NV7, 2QTU, 2YJD, 2YLY, 2Z4B, 3OLL, 3OLS, 3OMO, 3OMP, 3OMQ, 4J24, 4ZI1
Identifiers
Aliases	ESR2, ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2, estrogen receptor 2, ODG8
External IDs	OMIM: 601663; MGI: 109392; HomoloGene: 1100; GeneCards: ESR2; OMA:ESR2 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q23.2-q23.3 Start 64,084,232 bp[1] End 64,338,112 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12 C3|12 33.52 cM Start 76,167,193 bp[2] End 76,224,033 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right adrenal gland right adrenal cortex left adrenal gland left adrenal cortex secondary oocyte left ovary right ovary granulocyte epithelium of colon left testis Top expressed in zygote secondary oocyte primary oocyte urethra female urethra male urethra cumulus cell lumbar subsegment of spinal cord embryo ovary More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity nuclear receptor activity metal ion binding steroid hormone receptor activity steroid binding zinc ion binding protein binding DNA binding sequence-specific DNA binding transcription coactivator activity receptor antagonist activity lipid binding enzyme binding estrogen response element binding core promoter sequence-specific DNA binding estrogen receptor activity identical protein binding DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding Cellular component mitochondrion nucleus nucleoplasm extracellular region Biological process regulation of transcription, DNA-templated transcription, DNA-templated negative regulation of cell growth transcription initiation from RNA polymerase II promoter positive regulation of DNA-binding transcription factor activity cell-cell signaling signal transduction extracellular negative regulation of signal transduction positive regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II intracellular estrogen receptor signaling pathway positive regulation of transcription by RNA polymerase II cellular response to estradiol stimulus negative regulation of signaling receptor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2100 13983 Ensembl ENSG00000140009 ENSMUSG00000021055 UniProt Q92731 O08537 RefSeq (mRNA) NM_001040275 NM_001040276 NM_001214902 NM_001214903 NM_001271876 NM_001271877 NM_001291712 NM_001291723 NM_001437 NM_010157 NM_207707 RefSeq (protein) NP_001035365 NP_001201831 NP_001258805 NP_001258806 NP_001278641 NP_001278652 NP_001428 NP_034287 NP_997590 Location (UCSC) Chr 14: 64.08 – 64.34 Mb Chr 12: 76.17 – 76.22 Mb PubMed search [3] [4]
Wikidata
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Estrogen receptor beta (ERβ) also known as NR3A2 (nuclear receptor subfamily 3, group A, member 2) is one of two main types of estrogen receptor—a nuclear receptor which is activated by the sex hormone estrogen.^[5] In humans ERβ is encoded by the ESR2 gene.^[6]