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Clinical data | |
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Other names | E1S; Oestrone sulfate; Estrone 3-sulfate; Estra-1,3,5(10)-trien-17-one 3-sulfate |
Routes of administration | By mouth, others[1][2][3] |
Drug class | Estrogen; Estrogen ester |
Pharmacokinetic data | |
Protein binding | 90%, to albumin, and not to SHBG[4] |
Metabolism | Desulfation (via STS )[6] |
Metabolites | • Estrone[1] • Estradiol[1] |
Elimination half-life | 12 hours[5] |
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Chemical and physical data | |
Formula | C18H22O5S |
Molar mass | 350.43 g·mol−1 |
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Estrone sulfate (E1S) is an estrogen medication and naturally occurring steroid hormone.[1] It is used in menopausal hormone therapy among other indications.[1][2] As the sodium salt (sodium estrone sulfate), it is the major estrogen component of conjugated estrogens (Premarin) and esterified estrogens (Estratab, Menest).[1][3] In addition, E1S is used on its own as the piperazine salt estropipate (piperazine estrone sulfate; Ogen).[1][3] The compound also occurs as a major and important metabolite of estradiol and estrone.[1] E1S is most commonly taken by mouth, but in the form of Premarin can also be taken by parenteral routes such as transdermal, vaginal, and injection.[1][2]
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