Factor X

F10
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1C5M, 1EZQ, 1F0R, 1F0S, 1FAX, 1FJS, 1G2L, 1G2M, 1HCG, 1IOE, 1IQE, 1IQF, 1IQG, 1IQH, 1IQI, 1IQJ, 1IQK, 1IQL, 1IQM, 1IQN, 1KSN, 1LPG, 1LPK, 1LPZ, 1LQD, 1MQ5, 1MQ6, 1NFU, 1NFW, 1NFX, 1NFY, 1P0S, 1V3X, 1WU1, 1XKA, 1XKB, 1Z6E, 2BMG, 2BOH, 2BOK, 2BQ6, 2BQ7, 2BQW, 2CJI, 2D1J, 2EI6, 2EI7, 2EI8, 2FZZ, 2G00, 2GD4, 2H9E, 2J2U, 2J34, 2J38, 2J4I, 2J94, 2J95, 2JKH, 2P16, 2P3F, 2P3T, 2P3U, 2P93, 2P94, 2P95, 2PHB, 2PR3, 2Q1J, 2RA0, 2UWL, 2UWO, 2UWP, 2VH0, 2VH6, 2VVC, 2VVU, 2VVV, 2VWL, 2VWM, 2VWN, 2VWO, 2W26, 2W3I, 2W3K, 2WYG, 2WYJ, 2XBV, 2XBW, 2XBX, 2XBY, 2XC0, 2XC4, 2XC5, 2Y5F, 2Y5G, 2Y5H, 2Y7X, 2Y7Z, 2Y80, 2Y81, 2Y82, 3CEN, 3CS7, 3ENS, 3FFG, 3HPT, 3IIT, 3K9X, 3KL6, 3Q3K, 3SW2, 3TK5, 3TK6, 4A7I, 3KQB, 3KQC, 3KQD, 3KQE, 3LIW, 3M36, 3M37, 4BTI, 4BTT, 4BTU, 4Y6D, 4Y71, 4Y76, 4Y79, 4Y7A, 4Y7B, 4ZHA, 4ZH8, 5K0H
Identifiers
Aliases	F10, FX, FXA, coagulation factor X
External IDs	OMIM: 613872; MGI: 103107; HomoloGene: 30976; GeneCards: F10; OMA:F10 - orthologs
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q34 Start 113,122,799 bp[1] End 113,149,529 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 A1.1|8 5.73 cM Start 13,087,308 bp[2] End 13,106,676 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver stromal cell of endometrium canal of the cervix gastric mucosa right coronary artery left uterine tube islet of Langerhans right lung left coronary artery gallbladder Top expressed in left lobe of liver yolk sac gallbladder blood sexually immature organism bone marrow primitive streak right lung lobe abdominal wall ileum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding peptidase activity protein binding serine-type peptidase activity serine-type endopeptidase activity phospholipid binding hydrolase activity Cellular component endoplasmic reticulum lumen intrinsic component of external side of plasma membrane plasma membrane extracellular region Golgi lumen extracellular space Biological process hemostasis positive regulation of protein kinase B signaling positive regulation of cell migration blood coagulation proteolysis endoplasmic reticulum to Golgi vesicle-mediated transport blood coagulation, extrinsic pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2159 14058 Ensembl ENSG00000126218 ENSMUSG00000031444 UniProt P00742 O88947 RefSeq (mRNA) NM_000504 NM_001312674 NM_001312675 NM_001242368 NM_007972 RefSeq (protein) NP_000495 NP_001299603 NP_001299604 NP_001229297 NP_031998 Location (UCSC) Chr 13: 113.12 – 113.15 Mb Chr 8: 13.09 – 13.11 Mb PubMed search [3] [4]
Wikidata
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Coagulation factor X (EC 3.4.21.6), or Stuart factor, is an enzyme of the coagulation cascade, encoded in humans by F10 gene.^[5] It is a serine endopeptidase (protease group S1, PA clan). Factor X is synthesized in the liver and requires vitamin K for its synthesis.

Factor X is activated, by hydrolysis, into factor Xa by both factor IX with its cofactor, factor VIII in a complex known as intrinsic pathway; and factor VII with its cofactor, tissue factor in a complex known as extrinsic pathway.^[6] It is therefore the first member of the final common pathway or thrombin pathway.

It acts by cleaving prothrombin in two places (an Arg-Thr and then an Arg-Ile bond), which yields the active thrombin. This process is optimized when factor Xa is complexed with activated co-factor V in the prothrombinase complex.

Factor Xa is inactivated by protein Z-dependent protease inhibitor (ZPI), a serine protease inhibitor (serpin). The affinity of this protein for factor Xa is increased 1000-fold by the presence of protein Z, while it does not require protein Z for inactivation of factor XI. Defects in protein Z lead to increased factor Xa activity and a propensity for thrombosis. The half life of factor X is 40–45 hours.