Fay and Wu's H

Fay and Wu's H is a statistical test created by and named after two researchers Justin Fay and Chung-I Wu.^[1] The purpose of the test is to distinguish between a DNA sequence evolving randomly ("neutrally") and one evolving under positive selection. This test is an advancement over Tajima's D,^[2] which is used to differentiate neutrally evolving sequences from those evolving non-randomly (through directional selection or balancing selection, demographic expansion or contraction or genetic hitchhiking). Fay and Wu's H is frequently used to identify sequences which have experienced selective sweeps in their evolutionary history.

^ Fay, JC.; Wu, CI. (July 2000). "Hitchhiking under positive Darwinian selection". Genetics. 155 (3): 1405–13. doi:10.1093/genetics/155.3.1405. PMC 1461156. PMID 10880498.
^ Tajima F (November 1989). "Statistical method for testing the neutral mutation hypothesis by DNA polymorphism". Genetics. 123 (3): 585–95. doi:10.1093/genetics/123.3.585. PMC 1203831. PMID 2513255.

[Fay-2000-1] Fay, JC.; Wu, CI. (July 2000). "Hitchhiking under positive Darwinian selection". Genetics. 155 (3): 1405–13. doi:10.1093/genetics/155.3.1405. PMC 1461156. PMID 10880498.

[Tajima_1989-2] Tajima F (November 1989). "Statistical method for testing the neutral mutation hypothesis by DNA polymorphism". Genetics. 123 (3): 585–95. doi:10.1093/genetics/123.3.585. PMC 1203831. PMID 2513255.

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