Feline infectious peritonitis

Feline infectious peritonitis
Feline infectious peritonitis
	FIP-infected kidney showing inflammatory response
Specialty	Infectious diseases
Symptoms	Initial phase: common cold-like symptoms. Later on: ataxia, muscle weakness, dysphagia. End phase: shortness of breath, urinary incontinence, paralysis.
Usual onset	Can take up to a year for symptoms to appear after exposure to virus
Duration	1-month or less average life expectancy after diagnosis, especially in kittens
Causes	Mutation of feline coronavirus
Prevention	Keeping cats indoor to prevent the spread of feline coronavirus
Treatment	UK, Australia, Netherlands: GS-441524 (given orally as tablets) and its parent drug remdesivir (given by intravenous or subcutaneous injection)
Prognosis	Usually fatal without treatment, but with GS-441524 treatment over 80% of treated cats make a full recovery.
Frequency	Common

Feline infectious peritonitis (FIP) is a common and aberrant immune response in cats to infection with feline coronavirus (FCoV).^[5]

^ Hartmann 2017. Coronavirus Infections (Canine and Feline), Including Feline Infectious Peritonitis. Chapter 224 p984-991. In Textbook of Internal Medicine, 4th Edition. Ettinger.
^ Kennedy and Little 2012. Infectious diseases, Chapter 33 p1038-1047. In The Cat. Clinical Medicine and Management, Little.
^ Pederson et al 2019. Efficacy and safety of the nucleoside analog GS-441524 for treatment of cats with naturally occurring feline infectious peritonitis. J Feline Med Surg.21: 271–281
^ Dickinson et al 2020. Antiviral treatment using the adenosine nucleoside analogue GS‐441524 in cats with clinically diagnosed neurological feline infectious peritonitis J Vet Intern Med. 2020 Jul; 34(4): 1587–1593
^ Addie, D.; Belák, S.; Boucraut-Baralon, C.; Egberink, H.; Frymus, T.; Gruffydd-Jones, T.; Hartmann, K.; Hosie, M. J.; Lloret, A. (11 July 2009). "Feline infectious peritonitis. ABCD guidelines on prevention and management". Journal of Feline Medicine and Surgery. 11 (7): 594–604. doi:10.1016/j.jfms.2009.05.008. PMC 7129471. PMID 19481039.