![]() | |
![]() | |
Clinical data | |
---|---|
Pronunciation | /ˌflʊəroʊˈjʊərəsɪl/[1] |
Trade names | Adrucil, others |
AHFS/Drugs.com | Monograph |
MedlinePlus | a682708 |
License data |
|
Pregnancy category |
|
Routes of administration | Intravenous, topical |
ATC code | |
Legal status | |
Legal status | |
Pharmacokinetic data | |
Bioavailability | 28 to 100% |
Protein binding | 8 to 12% |
Metabolism | Intracellular and liver (CYP-mediated) |
Elimination half-life | 16 minutes |
Excretion | Kidney |
Identifiers | |
| |
CAS Number | |
PubChem CID | |
IUPHAR/BPS | |
DrugBank | |
ChemSpider | |
UNII | |
KEGG | |
ChEBI | |
ChEMBL | |
CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.000.078 |
Chemical and physical data | |
Formula | C4H3FN2O2 |
Molar mass | 130.078 g·mol−1 |
3D model (JSmol) | |
Melting point | 282–283 °C (540–541 °F) |
| |
| |
(verify) |
Fluorouracil (5-FU, 5-fluorouracil), sold under the brand name Adrucil among others, is a cytotoxic chemotherapy medication used to treat cancer.[3] By intravenous injection it is used for treatment of colorectal cancer, oesophageal cancer, stomach cancer, pancreatic cancer, breast cancer, and cervical cancer.[3] As a cream it is used for actinic keratosis, basal cell carcinoma, and skin warts.[4][5]
Side effects of use by injection are common.[3] They may include inflammation of the mouth, loss of appetite, low blood cell counts, hair loss, and inflammation of the skin.[3] When used as a cream, irritation at the site of application usually occurs.[4] Use of either form in pregnancy may harm the fetus.[3] Fluorouracil is in the antimetabolite and pyrimidine analog families of medications.[6][7] How it works is not entirely clear, but it is believed to involve blocking the action of thymidylate synthase and thus stopping the production of DNA.[3]
Fluorouracil was patented in 1956 and came into medical use in 1962.[8] It is on the World Health Organization's List of Essential Medicines.[9] In 2021, it was the 281st most commonly prescribed medication in the United States, with more than 800,000 prescriptions.[10][11]
© MMXXIII Rich X Search. We shall prevail. All rights reserved. Rich X Search