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Other names | Plasma frozen within 24 hours after phlebotomy (FP24)[1] |
AHFS/Drugs.com | Micromedex Detailed Consumer Information |
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Fresh frozen plasma (FFP) is a blood product made from the liquid portion of whole blood.[3] It is used to treat conditions in which there are low blood clotting factors (INR > 1.5) or low levels of other blood proteins.[3][1] It may also be used as the replacement fluid in plasma exchange.[2][4] Using ABO compatible plasma, while not required, may be recommended.[5][6] Use as a volume expander is not recommended.[3] It is administered by slow injection into a vein.[2]
Side effects include nausea and itchiness.[3] Rarely there may be allergic reactions, blood clots, or infections.[1][3] It is unclear if use during pregnancy or breastfeeding is safe for the baby.[2] Greater care should be taken in people with protein S deficiency, IgA deficiency, or heart failure.[2] Fresh frozen plasma is made up of a complex mixture of water, proteins, carbohydrates, fats, and vitamins.[1] When frozen it lasts about a year.[1]
Plasma first came into medical use during the Second World War.[1] It is on the World Health Organization's List of Essential Medicines.[7] In the United Kingdom it costs about £30 per unit.[8] A number of other versions also exist including plasma frozen within 24 hours after phlebotomy, cryoprecipitate reduced plasma, thawed plasma, and solvent detergent plasma.[1]
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