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Names | |
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Pronunciation | /ˈɡæmə əˈmiːnoʊbjuːˈtɪrɪk ˈæsɪd/, /ˈɡæbə/ (GABA) |
Preferred IUPAC name
4-Aminobutanoic acid | |
Other names
γ-Aminobutanoic acid
4-Aminobutyric acid 3-Carboxypropylamine Piperidic acid Piperidinic acid | |
Identifiers | |
3D model (JSmol)
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906818 | |
ChEBI | |
ChEMBL | |
ChemSpider | |
DrugBank | |
ECHA InfoCard | 100.000.235 |
EC Number |
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49775 | |
KEGG | |
MeSH | gamma-Aminobutyric+Acid |
PubChem CID
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RTECS number |
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UNII | |
CompTox Dashboard (EPA)
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Properties | |
C4H9NO2 | |
Molar mass | 103.121 g·mol−1 |
Appearance | white microcrystalline powder |
Density | 1.11 g/mL |
Melting point | 203.7 °C (398.7 °F; 476.8 K) |
Boiling point | 247.9 °C (478.2 °F; 521.0 K) |
130 g/100 ml | |
log P | −3.17 |
Acidity (pKa) |
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Hazards | |
Occupational safety and health (OHS/OSH): | |
Main hazards
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Irritant, Harmful |
Lethal dose or concentration (LD, LC): | |
LD50 (median dose)
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12,680 mg/kg (mouse, oral) |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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GABA (gamma Aminobutyric acid, γ-Aminobutyric acid) is the chief inhibitory neurotransmitter in the developmentally mature mammalian central nervous system. Its principal role is reducing neuronal excitability throughout the nervous system.
GABA is sold as a dietary supplement in many countries. It has been traditionally thought that exogenous GABA (i.e., taken as a supplement) does not cross the blood–brain barrier, but data obtained from more recent research (2010s) in rats describes the notion as being unclear.[2][3]
The carboxylate form of GABA is γ-aminobutyrate.
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