GPER

GPER1
Identifiers
Aliases	GPER1, Gper1, 6330420K13Rik, CMKRL2, Ceprl, FEG-1, GPCR-Br, Gper, Gpr30, CEPR, DRY12, LERGU, LERGU2, LyGPR, mER, G protein-coupled estrogen receptor 1
External IDs	OMIM: 601805; MGI: 1924104; HomoloGene: 15855; GeneCards: GPER1; OMA:GPER1 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p22.3 Start 1,082,208 bp[1] End 1,093,815 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 G2 Start 139,408,906 bp[2] End 139,413,555 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of stomach middle frontal gyrus fundus frontal pole paraflocculus of cerebellum tendon of biceps brachii right lobe of liver apex of heart testicle right adrenal cortex Top expressed in external carotid artery otolith organ utricle internal carotid artery condyle fossa trigeminal ganglion epithelium of stomach substantia nigra hand More reference expression data BioGPS More reference expression data
Gene ontology Molecular function estrogen receptor activity steroid hormone binding chromatin binding protein binding signal transducer activity steroid binding G protein-coupled receptor activity steroid hormone receptor activity Cellular component cytoplasm endosome nuclear envelope membrane synapse trans-Golgi network mitochondrion perinuclear region of cytoplasm cytoskeleton nucleus cell projection mitochondrial membranes keratin filament dendritic shaft dendritic spine head endoplasmic reticulum dendritic spine membrane integral component of membrane recycling endosome Golgi apparatus plasma membrane intracellular anatomical structure presynaptic active zone axon early endosome axon terminus endoplasmic reticulum membrane postsynaptic density Golgi membrane integral component of plasma membrane cell junction dendrite cytoplasmic vesicle membrane presynaptic membrane cytoplasmic vesicle hippocampal mossy fiber to CA3 synapse Biological process positive regulation of protein phosphorylation positive regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of G protein-coupled receptor signaling pathway positive regulation of ERK1 and ERK2 cascade positive regulation of extrinsic apoptotic signaling pathway cell cycle negative regulation of inflammatory response cellular response to glucose stimulus steroid hormone mediated signaling pathway negative regulation of cell population proliferation apoptotic process negative regulation of fat cell differentiation negative regulation of leukocyte activation apoptotic chromosome condensation regulation of cytosolic calcium ion concentration positive regulation of neurotransmitter secretion negative regulation of gene expression nuclear fragmentation involved in apoptotic nuclear change positive regulation of endothelial cell apoptotic process positive regulation of inositol trisphosphate biosynthetic process positive regulation of cardiac vascular smooth muscle cell differentiation innate immune response inflammatory response positive regulation of MAPK cascade G protein-coupled receptor signaling pathway negative regulation of protein kinase B signaling cell differentiation immune system process negative regulation of cell cycle process positive regulation of release of sequestered calcium ion into cytosol negative regulation of lipid biosynthetic process nervous system development positive regulation of neurogenesis positive regulation of release of cytochrome c from mitochondria positive regulation of epidermal growth factor receptor signaling pathway positive regulation of insulin secretion negative regulation of vascular associated smooth muscle cell proliferation positive regulation of cell migration positive regulation of cytosolic calcium ion concentration cellular response to tumor necrosis factor cellular response to estradiol stimulus cellular response to peptide hormone stimulus positive regulation of gene expression cellular response to mineralocorticoid stimulus positive regulation of cell population proliferation negative regulation of ERK1 and ERK2 cascade negative regulation of DNA metabolic process positive regulation of transcription by RNA polymerase II positive regulation of uterine smooth muscle contraction neuronal action potential signal transduction mineralocorticoid receptor signaling pathway positive regulation of phosphatidylinositol 3-kinase signaling positive regulation of apoptotic process intracellular steroid hormone receptor signaling pathway positive regulation of protein localization to plasma membrane adenylate cyclase-activating G protein-coupled receptor signaling pathway modulation of chemical synaptic transmission Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2852 76854 Ensembl ENSG00000164850 ENSMUSG00000053647 UniProt Q99527 Q8BMP4 RefSeq (mRNA) NM_001031682 NM_001039966 NM_001098201 NM_001505 NM_029771 RefSeq (protein) NP_001035055 NP_001091671 NP_001496 NP_084047 Location (UCSC) Chr 7: 1.08 – 1.09 Mb Chr 5: 139.41 – 139.41 Mb PubMed search [3] [4]
Wikidata
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G protein-coupled estrogen receptor 1 (GPER), also known as G protein-coupled receptor 30 (GPR30), is a protein that in humans is encoded by the GPER gene.^[5] GPER binds to and is activated by the female sex hormone estradiol and is responsible for some of the rapid effects that estradiol has on cells.^[6]