GPR158

GPR158
Identifiers
Aliases	GPR158, G protein-coupled receptor 158
External IDs	OMIM: 614573; MGI: 2441697; HomoloGene: 19381; GeneCards: GPR158; OMA:GPR158 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	25,602,229 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	21,835,358 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; middle temporal gyrus; ; cerebellar vermis; ; Brodmann area 23; ; lateral nuclear group of thalamus; ; Brodmann area 46; ; pons; ; superior frontal gyrus; ; postcentral gyrus; ; primary visual cortex;
	Top expressed in
	superior frontal gyrus; ; primary visual cortex; ; dentate gyrus of hippocampal formation granule cell; ; cerebellar cortex; ; secondary oocyte; ; supraoptic nucleus; ; lumbar subsegment of spinal cord; ; neural layer of retina; ; CA3 field; ; lumbar spinal ganglion;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity;
Cellular component	integral component of membrane; plasma membrane; membrane;
Biological process	G protein-coupled receptor signaling pathway; protein localization to plasma membrane; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	57512
	241263
	ENSG00000151025
	ENSMUSG00000045967
	Q5T848
	Q8C419
	NM_020752
	NM_001004761; NM_175706
	NP_065803
	NP_001004761
	Wikidata
View/Edit Human	View/Edit Mouse

Probable G-protein coupled receptor 158 (GPR158), also known as the metabotropic glycine receptor (mGlyR),^[5] is a protein that in humans is encoded by the GPR158 gene.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000151025 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000045967 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Laboute T, Zucca S, Holcomb M, Patil DN, Garza C, Wheatley BA, Roy RN, Forli S, Martemyanov KA (March 2023). "Orphan receptor GPR158 serves as a metabotropic glycine receptor: mGlyR". Science. 379 (6639): 1352–1358. Bibcode:2023Sci...379.1352L. doi:10.1126/science.add7150. PMC 10751545. PMID 36996198. S2CID 257836784.
^ "Entrez Gene: GPR158 G protein-coupled receptor 158".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000151025 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000045967 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid36996198-5] Laboute T, Zucca S, Holcomb M, Patil DN, Garza C, Wheatley BA, Roy RN, Forli S, Martemyanov KA (March 2023). "Orphan receptor GPR158 serves as a metabotropic glycine receptor: mGlyR". Science. 379 (6639): 1352–1358. Bibcode:2023Sci...379.1352L. doi:10.1126/science.add7150. PMC 10751545. PMID 36996198. S2CID 257836784.

[entrez-6] "Entrez Gene: GPR158 G protein-coupled receptor 158".

[1]

[2]

[3]

[4]

[5]

[6]