GPR37

GPR37
Identifiers
Aliases	GPR37, EDNRBL, PAELR, hET(B)R-LP, G protein-coupled receptor 37
External IDs	OMIM: 602583; MGI: 1313297; HomoloGene: 3875; GeneCards: GPR37; OMA:GPR37 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	124,765,792 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	25,690,728 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; inferior ganglion of vagus nerve; ; optic nerve; ; middle frontal gyrus; ; subthalamic nucleus; ; medulla oblongata; ; ventral tegmental area; ; superior vestibular nucleus; ; external globus pallidus; ; inferior olivary nucleus;
	Top expressed in
	deep cerebellar nuclei; ; lumbar subsegment of spinal cord; ; globus pallidus; ; lateral geniculate nucleus; ; utricle; ; vestibular sensory epithelium; ; pontine nuclei; ; medial geniculate nucleus; ; anterior horn of spinal cord; ; ventral tegmental area;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	G protein-coupled peptide receptor activity; G protein-coupled receptor activity; heat shock protein binding; prosaposin receptor activity; peptide binding; signal transducer activity; Hsp70 protein binding; protein binding; ubiquitin protein ligase binding;
Cellular component	integral component of membrane; endoplasmic reticulum membrane; membrane; ubiquitin ligase complex; receptor complex; plasma membrane; integral component of plasma membrane; endoplasmic reticulum;
Biological process	G protein-coupled receptor signaling pathway; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; dopamine biosynthetic process; negative regulation of hydrogen peroxide-induced cell death; locomotion involved in locomotory behavior; positive regulation of MAPK cascade; signal transduction; positive regulation of dopamine metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	2861
	14763
	ENSG00000170775
	ENSMUSG00000039904
	O15354
	Q9QY42
	NM_005302
	NM_010338
	NP_005293
	NP_034468
	Wikidata
View/Edit Human	View/Edit Mouse

Probable G-protein coupled receptor 37 is a protein that in humans is encoded by the GPR37 gene.^[5]^[6]^[7] GPR37 is primarily found in the central nervous system (CNS), with significant expression observed in various CNS regions including the amygdala, basal ganglia (caudate, putamen, and nucleus accumbens), substantia nigra, hippocampus, frontal cortex, and hypothalamus, particularly noteworthy is its exceptionally elevated expression in the spinal cord.^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000170775 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000039904 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Marazziti D, Golini E, Gallo A, Lombardi MS, Matteoni R, Tocchini-Valentini GP (October 1997). "Cloning of GPR37, a gene located on chromosome 7 encoding a putative G-protein-coupled peptide receptor, from a human frontal brain EST library". Genomics. 45 (1): 68–77. doi:10.1006/geno.1997.4900. PMID 9339362.
^ "Entrez Gene: GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)".
^ Bolinger AA, Frazier A, La JH, Allen JA, Zhou J (September 2023). "Orphan G Protein-Coupled Receptor GPR37 as an Emerging Therapeutic Target". ACS Chemical Neuroscience. 14 (18): 3318–3334. doi:10.1021/acschemneuro.3c00479. PMC 11144446. PMID 37676000. S2CID 261580509.
^ Lonsdale J, Thomas J, Salvatore M, Phillips R, Lo E, Shad S, et al. (GTEx Consortium) (June 2013). "The Genotype-Tissue Expression (GTEx) project". Nature Genetics. 45 (6): 580–585. doi:10.1038/ng.2653. PMC 4010069. PMID 23715323.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000170775 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000039904 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9339362-5] Marazziti D, Golini E, Gallo A, Lombardi MS, Matteoni R, Tocchini-Valentini GP (October 1997). "Cloning of GPR37, a gene located on chromosome 7 encoding a putative G-protein-coupled peptide receptor, from a human frontal brain EST library". Genomics. 45 (1): 68–77. doi:10.1006/geno.1997.4900. PMID 9339362.

[entrez-6] "Entrez Gene: GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)".

[7] Bolinger AA, Frazier A, La JH, Allen JA, Zhou J (September 2023). "Orphan G Protein-Coupled Receptor GPR37 as an Emerging Therapeutic Target". ACS Chemical Neuroscience. 14 (18): 3318–3334. doi:10.1021/acschemneuro.3c00479. PMC 11144446. PMID 37676000. S2CID 261580509.

[8] Lonsdale J, Thomas J, Salvatore M, Phillips R, Lo E, Shad S, et al. (GTEx Consortium) (June 2013). "The Genotype-Tissue Expression (GTEx) project". Nature Genetics. 45 (6): 580–585. doi:10.1038/ng.2653. PMC 4010069. PMID 23715323.

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