GRK5

GRK5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4TNB, 4TND
Identifiers
Aliases	GRK5, GPRK5, G protein-coupled receptor kinase 5, FP2025
External IDs	OMIM: 600870; MGI: 109161; HomoloGene: 3879; GeneCards: GRK5; OMA:GRK5 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	119,459,745 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	61,084,406 bp
RNA expression pattern
	Top expressed in
	saphenous vein; ; pylorus; ; synovial joint; ; cardia; ; lower lobe of lung; ; pericardium; ; jejunal mucosa; ; synovial membrane; ; urethra; ; right lung;
	Top expressed in
	blood; ; zygote; ; granulocyte; ; tail of embryo; ; secondary oocyte; ; Gonadal ridge; ; genital tubercle; ; myocardium of ventricle; ; esophagus; ; morula;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; G protein-coupled receptor kinase activity; kinase activity; protein serine/threonine kinase activity; protein binding; phospholipid binding; ATP binding; protein kinase C binding; lipid binding; beta-adrenergic receptor kinase activity;
Cellular component	nuclear membrane; membrane; plasma membrane; nucleus; cytoplasm; cytosol; nuclear speck;
Biological process	phosphorylation; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; negative regulation of apoptotic process; Wnt signaling pathway; tachykinin receptor signaling pathway; regulation of cell cycle; protein phosphorylation; positive regulation of cell population proliferation; protein autophosphorylation; fat cell differentiation; signal transduction; apoptotic process; regulation of G protein-coupled receptor signaling pathway; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	2869
	14773
	ENSG00000198873
	ENSMUSG00000003228
	P34947
	Q8VEB1
	NM_005308
	NM_018869
	NP_005299
	NP_061357
	Wikidata
View/Edit Human	View/Edit Mouse

G protein-coupled receptor kinase 5 is a member of the G protein-coupled receptor kinase subfamily of the Ser/Thr protein kinases, and is most highly similar to GRK4 and GRK6.^[5]^[6]^[7] The protein phosphorylates the activated forms of G protein-coupled receptors to regulate their signaling.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000198873 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000003228 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kunapuli P, Benovic JL (Jun 1993). "Cloning and expression of GRK5: a member of the G protein-coupled receptor kinase family". Proceedings of the National Academy of Sciences. 90 (12): 5588–92. Bibcode:1993PNAS...90.5588K. doi:10.1073/pnas.90.12.5588. PMC 46766. PMID 7685906.
^ Premont RT, Inglese J, Lefkowitz RJ (1995). "Protein kinases that phosphorylate activated G protein-coupled receptors". The FASEB Journal. 9 (2): 175–182. doi:10.1096/fasebj.9.2.7781920. PMID 7781920. S2CID 20428064.
^ "Entrez Gene: GRK5 G protein-coupled receptor kinase 5".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000198873 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000003228 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7685906-5] Kunapuli P, Benovic JL (Jun 1993). "Cloning and expression of GRK5: a member of the G protein-coupled receptor kinase family". Proceedings of the National Academy of Sciences. 90 (12): 5588–92. Bibcode:1993PNAS...90.5588K. doi:10.1073/pnas.90.12.5588. PMC 46766. PMID 7685906.

[6] Premont RT, Inglese J, Lefkowitz RJ (1995). "Protein kinases that phosphorylate activated G protein-coupled receptors". The FASEB Journal. 9 (2): 175–182. doi:10.1096/fasebj.9.2.7781920. PMID 7781920. S2CID 20428064.

[entrez-7] "Entrez Gene: GRK5 G protein-coupled receptor kinase 5".

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