Glycolic acid

Glycolic acid
Chemical structure of glycolic acid
Chemical structure of glycolic acid
Ball-and-stick model of glycolic acid
Ball-and-stick model of glycolic acid
Glycolic acid
Names
Preferred IUPAC name
Hydroxyacetic acid
Other names
Hydroacetic acid
2-Hydroxyethanoic acid
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
DrugBank
ECHA InfoCard 100.001.073 Edit this at Wikidata
EC Number
  • 201-180-5
KEGG
RTECS number
  • MC5250000
UNII
  • InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5) checkY
    Key: AEMRFAOFKBGASW-UHFFFAOYSA-N checkY
  • InChI=1/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)
    Key: AEMRFAOFKBGASW-UHFFFAOYAR
  • OC(=O)CO
Properties
C2H4O3
Molar mass 76.05 g/mol
Appearance White powder or colorless crystals
Density 1.49 g/cm3[1]
Melting point 75 °C (167 °F; 348 K)
Boiling point 100 °C (212 °F; 373 K) Decomposes above 100 °C
70% solution
Solubility in other solvents Alcohols, acetone,
acetic acid and
ethyl acetate[2]
log P −1.05[3]
Vapor pressure 1.051 kPa (80 °C)
Acidity (pKa) 3.83
Hazards
Occupational safety and health (OHS/OSH):
Main hazards
Corrosive
GHS labelling:
GHS05: CorrosiveGHS07: Exclamation mark
Danger
H302, H314, H332
P260, P261, P264, P270, P271, P280, P301+P312, P301+P330+P331, P303+P361+P353, P304+P312, P304+P340, P305+P351+P338, P310, P312, P321, P330, P363, P405, P501
NFPA 704 (fire diamond)
NFPA 704 four-colored diamondHealth 3: Short exposure could cause serious temporary or residual injury. E.g. chlorine gasFlammability 1: Must be pre-heated before ignition can occur. Flash point over 93 °C (200 °F). E.g. canola oilInstability 1: Normally stable, but can become unstable at elevated temperatures and pressures. E.g. calciumSpecial hazards (white): no code
3
1
1
Flash point 300 °C (572 °F; 573 K)[4]
Lethal dose or concentration (LD, LC):
1950 mg/kg (rat, oral)
2040 mg/kg (rat, oral)
7.7 ppm (rat, 4h)
3.6 ppm (rat, 4h)
Related compounds
Lactic acid
Related compounds
Glycolaldehyde
Acetic acid
Glycerol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Glycolic acid (or hydroxyacetic acid; chemical formula HOCH2CO2H) is a colorless, odorless and hygroscopic crystalline solid, highly soluble in water. It is used in various skin-care products. Glycolic acid is widespread in nature. A glycolate (sometimes spelled "glycollate") is a salt or ester of glycolic acid.

  1. ^ United States National Library of Medicine "Hydroxyacetic Acid" in TOXNET Hazardous Substances Data Bank (HSDB), citing Gerhartz, W. (exec ed.), Ullmann's Encyclopedia of Industrial Chemistry. 5th ed.Vol A1: Deerfield Beach, FL: VCH Publishers, 1985 to Present., p. VA13 509.
  2. ^ "DuPont Glycolic Acid Technical Information". Archived from the original on 2006-07-14. Retrieved 2006-07-06.
  3. ^ "Glycolic acid". www.chemsrc.com. Archived from the original on 2020-07-27. Retrieved 2018-05-16.
  4. ^ "Glycolic Acid MSDS". University of Akron. Retrieved 2006-09-18.[permanent dead link]

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