Gnotobiosis

Gnotobiosis (from Greek roots gnostos "known" and bios "life") refers to an engineered state of an organism in which all forms of life (i.e., microorganisms) in or on it, including its microbiota, have been identified.^[1] The term gnotobiotic organism, or gnotobiote, can refer to a model organism that is colonized with a specific community of known microorganisms (isobiotic or defined flora animal) or that contains no microorganisms (germ-free) often for experimental purposes.^[2]^[3]^[4]^[5] The study of gnotobiosis and the generation of various types of gnotobiotic model organisms as tools for studying interactions between host organisms and microorganisms is referred to as gnotobiology.^[2]

^ Basic M, Bleich A (June 2019). "Gnotobiotics: Past, present and future". Laboratory Animals. 53 (3): 232–243. doi:10.1177/0023677219836715. PMID 31096878. S2CID 157056547.
^ ^a ^b Cite error: The named reference :02 was invoked but never defined (see the help page).
^ Alper A, Anestidou L, Ogilvie J (2018). Animal models for microbiome research : advancing basic and translational science: proceedings of a workshop. Washington, DC: Engineering, and Medicine. Division on Earth and Life Studies National Academies of Sciences, Institute for Laboratory Animal Research. Roundtable on Science and Welfare in Laboratory Animal Use. pp. 1–2, 7–13. ISBN 978-0-309-46389-8. OCLC 1034579585.
^ Cite error: The named reference :3 was invoked but never defined (see the help page).
^ Cite error: The named reference :6 was invoked but never defined (see the help page).

[1] Basic M, Bleich A (June 2019). "Gnotobiotics: Past, present and future". Laboratory Animals. 53 (3): 232–243. doi:10.1177/0023677219836715. PMID 31096878. S2CID 157056547.

[:02-2] Cite error: The named reference :02 was invoked but never defined (see the help page).

[:4-3] Alper A, Anestidou L, Ogilvie J (2018). Animal models for microbiome research : advancing basic and translational science: proceedings of a workshop. Washington, DC: Engineering, and Medicine. Division on Earth and Life Studies National Academies of Sciences, Institute for Laboratory Animal Research. Roundtable on Science and Welfare in Laboratory Animal Use. pp. 1–2, 7–13. ISBN 978-0-309-46389-8. OCLC 1034579585.

[:3-4] Cite error: The named reference :3 was invoked but never defined (see the help page).

[:6-5] Cite error: The named reference :6 was invoked but never defined (see the help page).

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