guanine nucleotide binding protein (G protein), q polypeptide | |||||||
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Identifiers | |||||||
Symbol | GNAQ | ||||||
NCBI gene | 2776 | ||||||
HGNC | 4390 | ||||||
OMIM | 600998 | ||||||
RefSeq | NM_002072 | ||||||
UniProt | P50148 | ||||||
Other data | |||||||
Locus | Chr. 9 q21 | ||||||
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guanine nucleotide binding protein (G protein), alpha 11 (Gq class) | |||||||
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Identifiers | |||||||
Symbol | GNA11 | ||||||
NCBI gene | 2767 | ||||||
HGNC | 4379 | ||||||
OMIM | 139313 | ||||||
RefSeq | NM_002067 | ||||||
UniProt | P29992 | ||||||
Other data | |||||||
Locus | Chr. 19 p13.3 | ||||||
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guanine nucleotide binding protein (G protein), alpha 14 | |||||||
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Identifiers | |||||||
Symbol | GNA14 | ||||||
NCBI gene | 9630 | ||||||
HGNC | 4382 | ||||||
OMIM | 604397 | ||||||
RefSeq | NM_004297 | ||||||
UniProt | O95837 | ||||||
Other data | |||||||
Locus | Chr. 9 q21 | ||||||
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guanine nucleotide binding protein (G protein), alpha 15 (Gq class) | |||||||
---|---|---|---|---|---|---|---|
Identifiers | |||||||
Symbol | GNA15 | ||||||
NCBI gene | 2769 | ||||||
HGNC | 4383 | ||||||
OMIM | 139314 | ||||||
RefSeq | NM_002068 | ||||||
UniProt | P30679 | ||||||
Other data | |||||||
Locus | Chr. 19 p13.3 | ||||||
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Gq protein alpha subunit is a family of heterotrimeric G protein alpha subunits. This family is also commonly called the Gq/11 (Gq/G11) family or Gq/11/14/15 family to include closely related family members. G alpha subunits may be referred to as Gq alpha, Gαq, or Gqα. Gq proteins couple to G protein-coupled receptors to activate beta-type phospholipase C (PLC-β) enzymes. PLC-β in turn hydrolyzes phosphatidylinositol 4,5-bisphosphate (PIP2) to diacyl glycerol (DAG) and inositol trisphosphate (IP3). IP3 acts as a second messenger to release stored calcium into the cytoplasm, while DAG acts as a second messenger that activates protein kinase C (PKC).
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