Gram domain containing 1a

GRAMD1A
Identifiers
Aliases	GRAMD1A, KIAA1533, GRAM domain containing 1A, Aster-A
External IDs	MGI: 105490; HomoloGene: 10843; GeneCards: GRAMD1A; OMA:GRAMD1A - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	35,026,471 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	30,855,321 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; upper lobe of left lung; ; right uterine tube; ; left uterine tube; ; canal of the cervix; ; left ovary; ; right ovary; ; gastric mucosa; ; appendix; ; right lung;
	Top expressed in
	granulocyte; ; thymus; ; lymph node; ; superior frontal gyrus; ; ganglionic eminence; ; muscle of thigh; ; visual cortex; ; primary visual cortex; ; ventricular zone; ; interventricular septum;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; cholesterol binding; cholesterol transfer activity; lipid binding;
Cellular component	membrane; integral component of membrane; intrinsic component of endoplasmic reticulum membrane; extrinsic component of cytoplasmic side of plasma membrane; organelle membrane contact site; endoplasmic reticulum; endoplasmic reticulum membrane; plasma membrane; endoplasmic reticulum-plasma membrane contact site;
Biological process	cholesterol transport; cellular response to cholesterol; intermembrane sterol transfer; lipid transport;
	Sources:Amigo / QuickGO
Orthologs
	57655
	52857
	ENSG00000089351
	ENSMUSG00000001248
	Q96CP6
	Q8VEF1
	NM_001136199; NM_020895; NM_001320034; NM_001320035; NM_001320036
	NM_027898; NM_001360351
	NP_001129671; NP_001306963; NP_001306964; NP_001306965; NP_065946
	NP_082174; NP_001347280
	Wikidata
View/Edit Human	View/Edit Mouse

GRAM domain containing 1A also known as Aster-A is a protein that is encoded by the GRAMD1A gene. ^[5]^[6] It contains a transmembrane region, a GRAM domain and a VASt domain that can bind cholesterol.^[7]^[8] GRAMD1A has four paralogs: GRAMD1B and GRAMD1C and two without VASt domains, GRAMD2A and GRAMD2B. These proteins are mammalian representatives of the yeast lipid transfer proteins anchored at a membrane contact site (LAM) family.^[7]

The protein is expressed ubiquitously with higher levels in the central nervous system.^[9]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000089351 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000001248 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: GRAM domain containing 1A". Retrieved 2017-09-15.
^ "UniProtKB - Q8VEF1 (ASTRA_MOUSE)". Retrieved March 6, 2020.
^ ^a ^b Besprozvannaya M, Dickson E, Li H, Ginburg KS, Bers DM, Auwerx J, Nunnari J (February 2018). "GRAM domain proteins specialize functionally distinct ER-PM contact sites in human cells". eLife. 22 (7): e31019. doi:10.7554/eLife.31019. PMC 5823543. PMID 29469807.
^ Sandhu J, Li S, Fairall L, Pfisterer SG, Gurnett JE, Xiao X, Weston TA, Vashi D, Ferrari A, Orozco JL, Hartman CL, Strugatsky D, Lee SD, He C, Hong C, Jiang H, Bentolila LA, Gatta AT, Levine TP, Ferng A, Lee R, Ford DA, Young SG, Ikonen E, Schwabe JW, Tontonoz P (October 2018). "Aster Proteins Facilitate Nonvesicular Plasma Membrane to ER Cholesterol Transport in Mammalian Cells". Cell. 175 (2): 514–529.e20. doi:10.1016/j.cell.2018.08.033. PMC 6469685. PMID 30220461.
^ Naito T, Saheki Y (August 2021). "GRAMD1-mediated accessible cholesterol sensing and transport". Biochim Biophys Acta Mol Cell Biol Lipids. 1866 (8): 158957. doi:10.1016/j.bbalip.2021.158957. PMID 33932585. S2CID 233477388.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000089351 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000001248 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: GRAM domain containing 1A". Retrieved 2017-09-15.

[6] "UniProtKB - Q8VEF1 (ASTRA_MOUSE)". Retrieved March 6, 2020.

[pmid29469807-7] Besprozvannaya M, Dickson E, Li H, Ginburg KS, Bers DM, Auwerx J, Nunnari J (February 2018). "GRAM domain proteins specialize functionally distinct ER-PM contact sites in human cells". eLife. 22 (7): e31019. doi:10.7554/eLife.31019. PMC 5823543. PMID 29469807.

[Sandhu_et_al.-8] Sandhu J, Li S, Fairall L, Pfisterer SG, Gurnett JE, Xiao X, Weston TA, Vashi D, Ferrari A, Orozco JL, Hartman CL, Strugatsky D, Lee SD, He C, Hong C, Jiang H, Bentolila LA, Gatta AT, Levine TP, Ferng A, Lee R, Ford DA, Young SG, Ikonen E, Schwabe JW, Tontonoz P (October 2018). "Aster Proteins Facilitate Nonvesicular Plasma Membrane to ER Cholesterol Transport in Mammalian Cells". Cell. 175 (2): 514–529.e20. doi:10.1016/j.cell.2018.08.033. PMC 6469685. PMID 30220461.

[Naito-9] Naito T, Saheki Y (August 2021). "GRAMD1-mediated accessible cholesterol sensing and transport". Biochim Biophys Acta Mol Cell Biol Lipids. 1866 (8): 158957. doi:10.1016/j.bbalip.2021.158957. PMID 33932585. S2CID 233477388.

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