Gram domain containing 1b

GRAMD1B
Identifiers
Aliases	GRAMD1B, GRAM domain containing 1B, LINC01059, Aster-B
External IDs	MGI: 1925037; HomoloGene: 18223; GeneCards: GRAMD1B; OMA:GRAMD1B - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q24.1 Start 123,358,428 bp[1] End 123,627,774 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 A5.1 Start 40,293,233 bp[2] End 40,531,383 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left adrenal gland right adrenal gland paraflocculus of cerebellum right adrenal cortex left adrenal cortex trigeminal ganglion right hemisphere of cerebellum lateral nuclear group of thalamus spinal ganglia Parietal Lobe Top expressed in neural layer of retina cerebellar cortex yolk sac decidua adrenal medulla visual cortex superior frontal gyrus primary visual cortex dentate gyrus of hippocampal formation granule cell lobe of cerebellum More reference expression data BioGPS n/a
Gene ontology Molecular function phosphatidylserine binding lipid binding cholesterol binding phosphatidic acid binding cholesterol transfer activity Cellular component membrane integral component of membrane endoplasmic reticulum endoplasmic reticulum membrane plasma membrane endoplasmic reticulum-plasma membrane contact site Biological process lipid transport cholesterol transport cholesterol homeostasis cellular response to cholesterol intermembrane sterol transfer Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57476 235283 Ensembl ENSG00000023171 ENSMUSG00000040111 UniProt Q3KR37 Q80TI0 RefSeq (mRNA) NM_001286563 NM_001286564 NM_020716 NM_001330396 NM_172768 NM_001357617 NM_001357618 NM_001357619 NM_001357620 NM_001357621 NM_001357622 NM_001357623 RefSeq (protein) NP_001273492 NP_001273493 NP_001317325 NP_065767 NP_001341766 NP_001354347 NP_001354348 NP_001354349 NP_001354350 NP_766356 NP_001344546 NP_001344547 NP_001344548 NP_001344549 NP_001344550 NP_001344551 NP_001344552 Location (UCSC) Chr 11: 123.36 – 123.63 Mb Chr 9: 40.29 – 40.53 Mb PubMed search [3] [4]
Wikidata
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GRAM domain containing 1B, also known as GRAMD1B, Aster-B and KIAA1201, is a cholesterol transport protein that is encoded by the GRAMD1B gene.^[5][6][7][8] It contains a transmembrane region and two domains of known function; the GRAM domain and a VASt domain. It is anchored to the endoplasmic reticulum.^[7] This highly conserved gene is found in a variety of vertebrates and invertebrates. Homologs (Lam/Ltc proteins) are found in yeast.^[7]