Granulin

GRN
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1G26, 2JYE, 2JYT, 2JYU, 2JYV
Identifiers
Aliases	GRN, CLN11, GEP, GP88, PCDGF, PEPI, PGranulin, granulin precursor
External IDs	OMIM: 138945; MGI: 95832; HomoloGene: 1577; GeneCards: GRN; OMA:GRN - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.31 Start 44,345,246 bp[1] End 44,353,106 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 D|11 66.29 cM Start 102,321,141 bp[2] End 102,327,874 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte stromal cell of endometrium spleen right lung upper lobe of left lung gallbladder minor salivary glands bone marrow cells transverse colon right coronary artery Top expressed in aortic valve ascending aorta ciliary body internal carotid artery external carotid artery Paneth cell utricle carotid body iris supraoptic nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cytokine activity growth factor activity protein binding RNA binding chaperone binding Cellular component extracellular exosome extracellular region extracellular space lysosome endosome endoplasmic reticulum azurophil granule lumen lysosomal membrane late endosome Golgi apparatus trans-Golgi network plasma membrane membrane Biological process signal transduction neutrophil degranulation regulation of signaling receptor activity positive regulation of cell migration astrocyte activation involved in immune response microglial cell activation involved in immune response lysosome organization lysosomal transport lysosomal lumen acidification positive regulation of endothelial cell migration negative regulation of neuron apoptotic process positive regulation of neuron apoptotic process positive regulation of angiogenesis positive regulation of axon regeneration positive regulation of epithelial cell proliferation protein stabilization negative regulation of respiratory burst involved in inflammatory response positive regulation of inflammatory response to wounding positive regulation of defense response to bacterium negative regulation of neutrophil activation positive regulation of protein folding negative regulation of microglial cell activation positive regulation of aspartic-type peptidase activity positive regulation of lysosome organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2896 14824 Ensembl ENSG00000030582 ENSMUSG00000034708 UniProt P28799 P28798 RefSeq (mRNA) NM_001012479 NM_002087 NM_008175 RefSeq (protein) NP_002078 NP_032201 Location (UCSC) Chr 17: 44.35 – 44.35 Mb Chr 11: 102.32 – 102.33 Mb PubMed search [3] [4]
Wikidata
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Granulin
The solution structure of a well-folded peptide based on the 31-residue amino-terminal subdomain of human granulin a
Identifiers
Symbol	Granulin
Pfam	PF00396
InterPro	IPR000118
PROSITE	PDOC00634
SCOP2	1pcn / SCOPe / SUPFAM
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Granulin is a protein that in humans is encoded by the GRN gene.^[5][6][7] Each granulin protein is cleaved from the precursor progranulin, a 593 amino-acid-long and 68.5 kDa protein.^[8] While the function of progranulin and granulin have yet to be determined, both forms of the protein have been implicated in development, inflammation, cell proliferation and protein homeostasis. The 2006 discovery of the GRN mutation in a population of patients with frontotemporal dementia has spurred much research in uncovering the function and involvement in disease of progranulin in the body. While there is a growing body of research on progranulin's role in the body, studies on specific granulin residues are still limited.