HRAS

HRAS
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 121P, 1AA9, 1AGP, 1BKD, 1CLU, 1CRP, 1CRQ, 1CRR, 1CTQ, 1GNP, 1GNQ, 1GNR, 1HE8, 1IAQ, 1IOZ, 1JAH, 1JAI, 1K8R, 1LF0, 1LF5, 1LFD, 1NVU, 1NVV, 1NVW, 1NVX, 1P2S, 1P2T, 1P2U, 1P2V, 1PLJ, 1PLK, 1PLL, 1Q21, 1QRA, 1RVD, 1WQ1, 1XCM, 1XD2, 1XJ0, 1ZVQ, 1ZW6, 221P, 2C5L, 2CE2, 2CL0, 2CL6, 2CL7, 2CLC, 2CLD, 2EVW, 2LCF, 2LWI, 2Q21, 2QUZ, 2RGA, 2RGB, 2RGC, 2RGD, 2RGE, 2RGG, 2UZI, 2VH5, 2X1V, 3DDC, 3I3S, 3K8Y, 3K9L, 3K9N, 3KKM, 3KKN, 3KUD, 3L8Y, 3L8Z, 3LBH, 3LBI, 3LBN, 3LO5, 3OIU, 3OIV, 3OIW, 3RRY, 3RRZ, 3RS0, 3RS2, 3RS3, 3RS4, 3RS5, 3RS7, 3RSL, 3RSO, 421P, 4DLR, 4DLS, 4DLT, 4DLU, 4DLV, 4DLW, 4DLX, 4DLY, 4DLZ, 4EFL, 4EFM, 4EFN, 4G0N, 4G3X, 4K81, 4Q21, 521P, 5P21, 621P, 6Q21, 721P, 821P, 4L9S, 4L9W, 4NYI, 4NYJ, 4NYM, 4URU, 4URV, 4URW, 4URX, 4URY, 4URZ, 4US0, 4US1, 4US2, 2N42, 2N46, 4XVQ, 4XVR, 4RSG, 5B30
Identifiers
Aliases	HRAS, C-BAS/HAS, C-H-RAS, C-HA-RAS1, CTLO, H-RASIDX, HAMSV, HRAS1, RASH1, p21ras, Harvey rat sarcoma viral oncogene homolog, HRas proto-oncogene, GTPase, RASK2
External IDs	OMIM: 190020; MGI: 96224; HomoloGene: 55890; GeneCards: HRAS; OMA:HRAS - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.5 Start 532,242 bp[1] End 537,321 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 F5|7 86.48 cM Start 140,769,018 bp[2] End 140,773,918 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of abdomen skin of leg putamen caudate nucleus nucleus accumbens hypothalamus temporal lobe amygdala right hemisphere of cerebellum substantia nigra Top expressed in dentate gyrus of hippocampal formation granule cell lip molar superior frontal gyrus esophagus fetal liver hematopoietic progenitor cell yolk sac entorhinal cortex perirhinal cortex muscle of thigh More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding protein C-terminus binding protein binding GTPase activity GTP binding GDP binding Cellular component cytoplasm cytosol Golgi apparatus intracellular membrane-bounded organelle membrane Golgi membrane plasma membrane perinuclear region of cytoplasm nucleus glutamatergic synapse Biological process negative regulation of neuron apoptotic process defense response to protozoan positive regulation of protein phosphorylation regulation of long-term neuronal synaptic plasticity endocytosis positive regulation of MAP kinase activity positive regulation of miRNA metabolic process positive regulation of epithelial cell proliferation positive regulation of ruffle assembly mitotic cell cycle checkpoint signaling positive regulation of cell migration ephrin receptor signaling pathway positive regulation of wound healing positive regulation of Ras protein signal transduction positive regulation of interferon-gamma production stimulatory C-type lectin receptor signaling pathway positive regulation of JNK cascade negative regulation of gene expression MAPK cascade intrinsic apoptotic signaling pathway positive regulation of GTPase activity chemotaxis cell surface receptor signaling pathway positive regulation of gene expression negative regulation of GTPase activity positive regulation of cell population proliferation positive regulation of ERK1 and ERK2 cascade animal organ morphogenesis T-helper 1 type immune response Ras protein signal transduction cell population proliferation T cell receptor signaling pathway positive regulation of actin cytoskeleton reorganization positive regulation of MAPK cascade negative regulation of cell population proliferation positive regulation of transcription by RNA polymerase II signal transduction apoptotic process small GTPase mediated signal transduction cellular senescence response to isolation stress cellular response to gamma radiation positive regulation of DNA replication positive regulation of phospholipase C activity protein heterooligomerization positive regulation of protein targeting to membrane regulation of neurotransmitter receptor localization to postsynaptic specialization membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3265 15461 Ensembl ENSG00000276536 ENSG00000174775 ENSMUSG00000025499 UniProt P01112 Q61411 RefSeq (mRNA) NM_001130442 NM_005343 NM_176795 NM_001318054 NM_001130443 NM_001130444 NM_008284 RefSeq (protein) NP_001123914 NP_001304983 NP_005334 NP_789765 NP_001123915 NP_001123916 NP_032310 Location (UCSC) Chr 11: 0.53 – 0.54 Mb Chr 7: 140.77 – 140.77 Mb PubMed search [3] [4]
Wikidata
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GTPase HRas, from "Harvey Rat sarcoma virus", also known as transforming protein p21 is an enzyme that in humans is encoded by the HRAS gene.^[5][6] The HRAS gene is located on the short (p) arm of chromosome 11 at position 15.5, from base pair 522,241 to base pair 525,549.^[7] HRas is a small G protein in the Ras subfamily of the Ras superfamily of small GTPases. Once bound to Guanosine triphosphate, H-Ras will activate a Raf kinase like c-Raf, the next step in the MAPK/ERK pathway.