HSAB theory

HSAB is an acronym for "hard and soft (Lewis) acids and bases". HSAB is widely used in chemistry for explaining the stability of compounds, reaction mechanisms and pathways. It assigns the terms 'hard' or 'soft', and 'acid' or 'base' to chemical species. 'Hard' applies to species which are small, have high charge states (the charge criterion applies mainly to acids, to a lesser extent to bases), and are weakly polarizable. 'Soft' applies to species which are big, have low charge states and are strongly polarizable.^[1]

The theory is used in contexts where a qualitative, rather than quantitative, description would help in understanding the predominant factors which drive chemical properties and reactions. This is especially so in transition metal chemistry, where numerous experiments have been done to determine the relative ordering of ligands and transition metal ions in terms of their hardness and softness.

HSAB theory is also useful in predicting the products of metathesis reactions. In 2005 it was shown that even the sensitivity and performance of explosive materials can be explained on basis of HSAB theory.^[2]

Ralph Pearson introduced the HSAB principle in the early 1960s^[3]^[4]^[5] as an attempt to unify inorganic and organic reaction chemistry.^[6]

^ Jolly, W. L. (1984). Modern Inorganic Chemistry. New York: McGraw-Hill. ISBN 978-0-07-032760-3.
^ [1] E.-C. Koch, Acid-Base Interactions in Energetic Materials: I. The Hard and Soft Acids and Bases (HSAB) Principle-Insights to Reactivity and Sensitivity of Energetic Materials, Prop.,Expl.,Pyrotech. 30 2005, 5
^ Pearson, Ralph G. (1963). "Hard and Soft Acids and Bases". J. Am. Chem. Soc. 85 (22): 3533–3539. doi:10.1021/ja00905a001.
^ Pearson, Ralph G. (1968). "Hard and soft acids and bases, HSAB, part 1: Fundamental principles". J. Chem. Educ. 1968 (45): 581–586. Bibcode:1968JChEd..45..581P. doi:10.1021/ed045p581.
^ Pearson, Ralph G. (1968). "Hard and soft acids and bases, HSAB, part II: Underlying theories". J. Chem. Educ. 1968 (45): 643–648. Bibcode:1968JChEd..45..643P. doi:10.1021/ed045p643.
^ [2] R. G. Pearson, Chemical Hardness – Applications From Molecules to Solids, Wiley-VCH, Weinheim, 1997, 198 pp

[1] Jolly, W. L. (1984). Modern Inorganic Chemistry. New York: McGraw-Hill. ISBN 978-0-07-032760-3.

[2] [1] E.-C. Koch, Acid-Base Interactions in Energetic Materials: I. The Hard and Soft Acids and Bases (HSAB) Principle-Insights to Reactivity and Sensitivity of Energetic Materials, Prop.,Expl.,Pyrotech. 30 2005, 5

[3] Pearson, Ralph G. (1963). "Hard and Soft Acids and Bases". J. Am. Chem. Soc. 85 (22): 3533–3539. doi:10.1021/ja00905a001.

[4] Pearson, Ralph G. (1968). "Hard and soft acids and bases, HSAB, part 1: Fundamental principles". J. Chem. Educ. 1968 (45): 581–586. Bibcode:1968JChEd..45..581P. doi:10.1021/ed045p581.

[5] Pearson, Ralph G. (1968). "Hard and soft acids and bases, HSAB, part II: Underlying theories". J. Chem. Educ. 1968 (45): 643–648. Bibcode:1968JChEd..45..643P. doi:10.1021/ed045p643.

[6] [2] R. G. Pearson, Chemical Hardness – Applications From Molecules to Solids, Wiley-VCH, Weinheim, 1997, 198 pp

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