Back Hämagglutinin (Influenzavirus A) German Hemaglutinina (influenza) Spanish 헤마글루티닌 (인플루엔자) Korean Гемагглютинин вируса гриппа Russian 流感血凝素 Chinese
| Hemagglutinin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
&sq=BTS&lang=en&file=File:PDB_1hgd_EBI.jpg) | |||||||||
| Identifiers | |||||||||
| Symbol | Hemagglutinin | ||||||||
| Pfam | PF00509 | ||||||||
| InterPro | IPR001364 | ||||||||
| SCOP2 | 1hgd / SCOPe / SUPFAM | ||||||||
| OPM superfamily | 109 | ||||||||
| OPM protein | 6hjq | ||||||||
| |||||||||
| Influenza C hemagglutinin stalk | |||||||||
|---|---|---|---|---|---|---|---|---|---|
&sq=BTS&lang=en&file=File:PDB_1flc_EBI.jpg) x-ray structure of the haemagglutinin-esterase-fusion glycoprotein of influenza c virus | |||||||||
| Identifiers | |||||||||
| Symbol | Hema_stalk | ||||||||
| Pfam | PF08720 | ||||||||
| InterPro | IPR014831 | ||||||||
| SCOP2 | 1flc / SCOPe / SUPFAM | ||||||||
| OPM superfamily | 277 | ||||||||
| OPM protein | 2jrd | ||||||||
| |||||||||
Influenza hemagglutinin (HA) or haemagglutinin[p] (British English) is a homotrimeric glycoprotein found on the surface of influenza viruses and is integral to its infectivity.
Hemagglutinin is a Class I Fusion Protein, having multifunctional activity as both an attachment factor and membrane fusion protein. Therefore, HA is responsible for binding Influenza virus to sialic acid on the surface of target cells, such as cells in the upper respiratory tract or erythrocytes,[1] causing as a result the internalization of the virus.[2] Secondarily, HA is responsible for the fusion of the viral envelope with the late endosomal membrane once exposed to low pH (5.0-5.5).[3]
The name "hemagglutinin" comes from the protein's ability to cause red blood cells (erythrocytes) to clump together ("agglutinate") in vitro.[4]
- ^ Russell RJ, Kerry PS, Stevens DJ, Steinhauer DA, Martin SR, Gamblin SJ, Skehel JJ (November 2008). "Structure of influenza hemagglutinin in complex with an inhibitor of membrane fusion". Proceedings of the National Academy of Sciences of the United States of America. 105 (46): 17736–41. Bibcode:2008PNAS..10517736R. doi:10.1073/pnas.0807142105. PMC 2584702. PMID 19004788.
- ^ Edinger, Thomas O.; Pohl, Marie O.; Stertz, Silke (February 2014). "Entry of influenza A virus: host factors and antiviral targets" (PDF). The Journal of General Virology. 95 (Pt 2): 263–277. doi:10.1099/vir.0.059477-0. ISSN 1465-2099. PMID 24225499.
- ^ Horvath, Peter; Helenius, Ari; Yamauchi, Yohei; Banerjee, Indranil (12 July 2013). "High-Content Analysis of Sequential Events during the Early Phase of Influenza A Virus Infection". PLOS ONE. 8 (7): e68450. Bibcode:2013PLoSO...868450B. doi:10.1371/journal.pone.0068450. ISSN 1932-6203. PMC 3709902. PMID 23874633.
- ^ Nelson DL, Cox MM (2005). Lehninger's Principles of Biochemistry (4th ed.). New York: WH Freeman.
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