Histamine H4 receptor

HRH4
Identifiers
Aliases	HRH4, AXOR35, BG26, GPCR105, GPRv53, H4, H4R, HH4R, histamine receptor H4
External IDs	OMIM: 606792; MGI: 2429635; HomoloGene: 11002; GeneCards: HRH4; OMA:HRH4 - orthologs
Gene location (Human)
Chr.	Chromosome 18 (human)
End	24,479,961 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	13,155,939 bp
RNA expression pattern
	Top expressed in
	monocyte; ; bone marrow; ; gonad; ; tibialis anterior muscle; ; blood; ; appendix; ; deltoid muscle; ; duodenum; ; right lobe of liver; ; lymph node;
	Top expressed in
	embryo; ; spermatocyte; ; spermatid; ; vastus lateralis muscle; ; testicle; ; thymus;
	More reference expression data
	n/a
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity; histamine receptor activity; G protein-coupled serotonin receptor activity; G protein-coupled acetylcholine receptor activity; neurotransmitter receptor activity;
Cellular component	integral component of membrane; membrane; plasma membrane; integral component of plasma membrane; dendrite;
Biological process	positive regulation of cytosolic calcium ion concentration; regulation of MAPK cascade; signal transduction; inflammatory response; negative regulation of adenylate cyclase activity; G protein-coupled receptor signaling pathway; biological process; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway; chemical synaptic transmission; G protein-coupled serotonin receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	59340
	225192
	ENSG00000134489
	ENSMUSG00000037346
	Q9H3N8
	Q91ZY2
	NM_001143828; NM_001160166; NM_021624
	NM_153087
	NP_001137300; NP_001153638; NP_067637
	NP_694727
	Wikidata
View/Edit Human	View/Edit Mouse

The histamine H₄ receptor, like the other three histamine receptors, is a member of the G protein-coupled receptor superfamily that in humans is encoded by the HRH4 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000134489 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000037346 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Oda T, Morikawa N, Saito Y, Masuho Y, Matsumoto S (2000). "Molecular cloning and characterization of a novel type of histamine receptor preferentially expressed in leukocytes". J. Biol. Chem. 275 (47): 36781–6. doi:10.1074/jbc.M006480200. PMID 10973974.
^ Nakamura T, Itadani H, Hidaka Y, Ohta M, Tanaka K (2000). "Molecular cloning and characterization of a new human histamine receptor, HH4R". Biochem. Biophys. Res. Commun. 279 (2): 615–20. doi:10.1006/bbrc.2000.4008. PMID 11118334.
^ Nguyen T, Shapiro DA, George SR, Setola V, Lee DK, Cheng R, et al. (2001). "Discovery of a novel member of the histamine receptor family" (abstract). Mol. Pharmacol. 59 (3): 427–33. doi:10.1124/mol.59.3.427. PMID 11179435.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000134489 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000037346 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10973974-5] Oda T, Morikawa N, Saito Y, Masuho Y, Matsumoto S (2000). "Molecular cloning and characterization of a novel type of histamine receptor preferentially expressed in leukocytes". J. Biol. Chem. 275 (47): 36781–6. doi:10.1074/jbc.M006480200. PMID 10973974.

[pmid11118334-6] Nakamura T, Itadani H, Hidaka Y, Ohta M, Tanaka K (2000). "Molecular cloning and characterization of a new human histamine receptor, HH4R". Biochem. Biophys. Res. Commun. 279 (2): 615–20. doi:10.1006/bbrc.2000.4008. PMID 11118334.

[pmid11179435-7] Nguyen T, Shapiro DA, George SR, Setola V, Lee DK, Cheng R, et al. (2001). "Discovery of a novel member of the histamine receptor family" (abstract). Mol. Pharmacol. 59 (3): 427–33. doi:10.1124/mol.59.3.427. PMID 11179435.

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