Hologenomics

Hologenomics is the omics study of hologenomes. A hologenome is the whole set of genomes of a holobiont, an organism together with all co-habitating microbes, other life forms, and viruses.^[1] While the term hologenome originated from the hologenome theory of evolution, which postulates that natural selection occurs on the holobiont level,^[2] hologenomics uses an integrative framework to investigate interactions between the host and its associated species. Examples include gut microbe^[3] or viral^[4] genomes linked to human or animal genomes for host-microbe interaction research.^[5] Hologenomics approaches have also been used to explain genetic diversity in the microbial communities of marine sponges.^[6]

^ Rosenberg, Eugene; Zilber-Rosenberg, Ilana (2018-04-25). "The hologenome concept of evolution after 10 years". Microbiome. 6 (1): 78. doi:10.1186/s40168-018-0457-9. ISSN 2049-2618. PMC 5922317. PMID 29695294.
^ Number 6 in a series of 7 VHS recordings, A Decade of PCR: Celebrating 10 Years of Amplification, Cold Spring Harbor Laboratory Press, 1994. ISBN 0-87969-473-4.
^ Denman, Stuart E.; McSweeney, Christopher S. (2015-02-16). "The Early Impact of Genomics and Metagenomics on Ruminal Microbiology". Annual Review of Animal Biosciences. 3 (1): 447–465. doi:10.1146/annurev-animal-022114-110705. ISSN 2165-8102. PMID 25387109.
^ Patowary, Ashok; Chauhan, Rajendra Kumar; Singh, Meghna; KV, Shamsudheen; Periwal, Vinita; KP, Kushwaha; Sapkal, Gajanand N.; Bondre, Vijay P.; Gore, Milind M. (2012-01-01). "De novo identification of viral pathogens from cell culture hologenomes". BMC Research Notes. 5: 11. doi:10.1186/1756-0500-5-11. ISSN 1756-0500. PMC 3284880. PMID 22226071.
^ Miller, William B. Jr. (2013). The Microcosm Within: Evolution and Extinction in the Hologenome. Universal-Publishers. ISBN 978-1612332772.
^ Webster, Nicole S.; Thomas, Torsten (2016-05-04). "The Sponge Hologenome". mBio. 7 (2): e00135–16. doi:10.1128/mBio.00135-16. ISSN 2150-7511. PMC 4850255. PMID 27103626.

[1] Rosenberg, Eugene; Zilber-Rosenberg, Ilana (2018-04-25). "The hologenome concept of evolution after 10 years". Microbiome. 6 (1): 78. doi:10.1186/s40168-018-0457-9. ISSN 2049-2618. PMC 5922317. PMID 29695294.

[:0-2] Number 6 in a series of 7 VHS recordings, A Decade of PCR: Celebrating 10 Years of Amplification, Cold Spring Harbor Laboratory Press, 1994. ISBN 0-87969-473-4.

[3] Denman, Stuart E.; McSweeney, Christopher S. (2015-02-16). "The Early Impact of Genomics and Metagenomics on Ruminal Microbiology". Annual Review of Animal Biosciences. 3 (1): 447–465. doi:10.1146/annurev-animal-022114-110705. ISSN 2165-8102. PMID 25387109.

[4] Patowary, Ashok; Chauhan, Rajendra Kumar; Singh, Meghna; KV, Shamsudheen; Periwal, Vinita; KP, Kushwaha; Sapkal, Gajanand N.; Bondre, Vijay P.; Gore, Milind M. (2012-01-01). "De novo identification of viral pathogens from cell culture hologenomes". BMC Research Notes. 5: 11. doi:10.1186/1756-0500-5-11. ISSN 1756-0500. PMC 3284880. PMID 22226071.

[5] Miller, William B. Jr. (2013). The Microcosm Within: Evolution and Extinction in the Hologenome. Universal-Publishers. ISBN 978-1612332772.

[6] Webster, Nicole S.; Thomas, Torsten (2016-05-04). "The Sponge Hologenome". mBio. 7 (2): e00135–16. doi:10.1128/mBio.00135-16. ISSN 2150-7511. PMC 4850255. PMID 27103626.

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