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Holyoke is a city in Hampden County, Massachusetts, United States.
Holyoke may also refer to:
- Holyoke, Colorado, a home rule municipality in Phillips County, Colorado
- Holyoke Publishing, an American comic book publisher
- Holyoke Range, a traprock mountain range in Massachusetts
- Mount Holyoke, a mountain in the Holyoke Range
- Elizur Holyoke, namesake of Holyoke, Massachusetts
- Keith Holyoake, a former Prime Minister of New Zealand
- a fictional place
- Holyoke station, an Amtrak station
- Holyoke Heritage State Park
- Holyoke Automobile Company
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