Hyperhomocysteinemia | |
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Other names | Hyperhomocysteinaemia |
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Total plasma homocysteine | |
Specialty | Nutrition, medical genetics, endocrinology ![]() |
Hyperhomocysteinemia is a medical condition characterized by an abnormally high level of total homocysteine (that is, including homocystine and homocysteine-cysteine disulfide) in the blood, conventionally described as above 15 μmol/L.[1]
As a consequence of the biochemical reactions in which homocysteine is involved, deficiencies of vitamin B6, folic acid (vitamin B9), and vitamin B12 can lead to high homocysteine levels.[2] Other possible causes of hyperhomocysteinemia include genetics, excessive methionine intake, and other diseases.[3]
Hyperhomocysteinemia is typically managed with vitamin B6, vitamin B9 and vitamin B12 supplementation.[4] Hyperhomocysteinemia is a risk factor for cardiovascular disease; supplements of these vitamins may slightly reduce stroke outcome but not myocardial infarction, death from any cause or adverse events.[5]
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