In vitro fertilisation

In vitro fertilisation
This image shows intracytoplasmic sperm injection, the most commonly used IVF technique.
Specialty	Reproductive endocrinology and infertility
ICD-10-PCS	8E0ZXY1
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In vitro fertilisation (IVF) is a process of fertilisation where an egg is combined with sperm in vitro ("in glass"). The process involves monitoring and stimulating a woman's ovulatory process, removing an ovum or ova (egg or eggs) from their ovaries and letting a man's sperm fertilise them in a culture medium in a laboratory. After the fertilised egg (zygote) undergoes embryo culture for 2–6 days, it is transferred by catheter into the uterus, with the intention of establishing a successful pregnancy.

IVF is a type of assisted reproductive technology used for infertility treatment, gestational surrogacy, and, in combination with pre-implantation genetic testing, avoiding transmission of genetic conditions. A fertilised egg from a donor may implant into a surrogate's uterus, and the resulting child is genetically unrelated to the surrogate. Some countries have banned or otherwise regulate the availability of IVF treatment, giving rise to fertility tourism. Restrictions on the availability of IVF include costs and age, in order for a person to carry a healthy pregnancy to term.

In July 1978, Louise Brown was the first child successfully born after her mother received IVF treatment.^[1] Brown was born as a result of natural-cycle IVF, where no stimulation was made. The procedure took place at Dr Kershaw's Cottage Hospital (now Dr Kershaw's Hospice) in Royton, Oldham, England. Robert Edwards was awarded the Nobel Prize in Physiology or Medicine in 2010. The physiologist co-developed the treatment together with Patrick Steptoe and embryologist Jean Purdy but the latter two were not eligible for consideration as they had died and the Nobel Prize is not awarded posthumously.^[2][3]

Assisted by egg donation and IVF, there are many women who may be past their reproductive years, have infertile partners, have idiopathic female-fertility issues, or have reached menopause, that can still become pregnant. After the IVF treatment, some couples get pregnant without any fertility treatments.^[4] In 2023, it was estimated that twelve million children had been born worldwide using IVF and other assisted reproduction techniques.^[5] A 2019 study that explores 10 adjuncts with IVF (screening hysteroscopy, DHEA, testosterone, GH, aspirin, heparin, antioxidants, seminal plasma and PRP) suggests that until more evidence is done to show that these adjuncts are safe and effective, they should be avoided.^[6]