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Injection lipolysis is a controversial cosmetic procedure in which drug mixtures are injected into patients with the goal of destroying fat cells. This practice, using drugs generally based on phosphatidylcholine and deoxycholate (PCDC), evolved from the initial intravenous use of those drug formulations to treat blood disorders.[1][2]
While no placebo-controlled studies have demonstrated the safety or efficacy of this therapy, numerous retrospective studies of Lipostabil injections have reported the efficacy of this practice.[2][3][4][5][6][7][8][9][10] The mixture is injected directly into the subcutaneous fat through multiple microinjections administered over multiple treatment sessions. The desired result is the removal of localized fat deposits.[2]
^Ablon G, Rotunda, AM. (2004). "Treatment of lower eyelid fat pads using phosphatidylcholine: clinical trial and review". Dermatologic Surgery. 30 (3): 422–7. doi:10.1097/00042728-200403000-00020. PMID15008874.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^Hexsel, D., Serra, M., Mazzuco, R. (2003). "Phosphatidylcholine in the treatment of localized fat". Journal of Drugs in Dermatology. 2 (5): 511–8. PMID14558399.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^Rotunda, A.M., G. Ablon, and M.S. Kolodney (2005). "Lipomas treated with subcutaneous deoxycholate injections". Journal of the American Academy of Dermatology. 53 (6): 973–8. doi:10.1016/j.jaad.2005.07.068. PMID16310057.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^Bechara, F.G., Sand, M., Hoffmann, K., Sand, D., Altmeyer, P., and Stucker, M. (2007). "Fat tissue after lipolysis of lipomas: a histopathological and immunohistochemical study". Journal of Cutaneous Pathology. 34 (7): 552–7. doi:10.1111/j.1600-0560.2006.00651.x. PMID17576334. S2CID39429064.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^Bechara, F.G., Sand, M., Altmeyer, P., and Hoffmann, K. (2006). "Intralesional lipolysis with phosphatidylcholine for the treatment of lipomas: pilot study". Arch Dermatol. 142 (8): 1069–70. doi:10.1001/archderm.142.8.1069-b. PMID16924064.{{cite journal}}: CS1 maint: multiple names: authors list (link)