Integrin beta 2

ITGB2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1L3Y, 1YUK, 2JF1, 2P26, 2P28, 3K6S, 3K71, 3K72, 2V7D, 4NEH, 4NEN, 5E6X, 5E6V, 5E6S, 5E6R, 5E6W, 5ES4, 5E6U
Identifiers
Aliases	ITGB2, CD18, LAD, LCAMB, LFA-1, MAC-1, MF17, MFI7, integrin subunit beta 2
External IDs	OMIM: 600065; MGI: 96611; HomoloGene: 20092; GeneCards: ITGB2; OMA:ITGB2 - orthologs
Gene location (Human) Chr. Chromosome 21 (human)[1] Band 21q22.3 Start 44,885,953 bp[1] End 44,931,989 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 C1|10 39.72 cM Start 77,366,086 bp[2] End 77,401,542 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte monocyte blood spleen bone marrow cells appendix trabecular bone lymph node right lung upper lobe of left lung Top expressed in granulocyte stroma of bone marrow tibiofemoral joint spleen thymus mesenteric lymph nodes blood right lung lobe ankle joint subcutaneous adipose tissue More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein-containing complex binding metal ion binding protein binding protein heterodimerization activity ICAM-3 receptor activity protein kinase binding cell adhesion molecule binding heat shock protein binding amyloid-beta binding complement component C3b binding integrin binding signaling receptor activity cargo receptor activity Cellular component integral component of membrane extracellular vesicle integrin alphaL-beta2 complex membrane plasma membrane receptor complex cell surface integrin complex extracellular exosome specific granule membrane tertiary granule membrane ficolin-1-rich granule membrane focal adhesion external side of plasma membrane integrin alphaM-beta2 complex plasma membrane raft membrane raft cytoplasmic region protein-containing complex Biological process leukocyte cell-cell adhesion endodermal cell differentiation toll-like receptor 4 signaling pathway positive regulation of nitric oxide biosynthetic process heterotypic cell-cell adhesion cell-cell signaling human ageing receptor internalization leukocyte migration involved in inflammatory response natural killer cell activation cellular response to low-density lipoprotein particle stimulus extracellular matrix organization receptor clustering positive regulation of angiogenesis neutrophil chemotaxis cell adhesion positive regulation of NF-kappaB transcription factor activity regulation of cell shape regulation of immune response cellular extravasation integrin-mediated signaling pathway cell-matrix adhesion inflammatory response endothelial cell migration leukocyte migration regulation of peptidyl-tyrosine phosphorylation apoptotic process phagocytosis neutrophil degranulation microglial cell activation receptor-mediated endocytosis phagocytosis, engulfment cell migration cytokine-mediated signaling pathway positive regulation of superoxide anion generation cell adhesion mediated by integrin positive regulation of neutrophil degranulation negative regulation of dopamine metabolic process positive regulation of protein targeting to membrane amyloid-beta clearance cell-cell adhesion cell-cell adhesion via plasma-membrane adhesion molecules positive regulation of neuron death positive regulation of microglial cell activation neutrophil migration positive regulation of prostaglandin-E synthase activity positive regulation of leukocyte adhesion to vascular endothelial cell Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3689 16414 Ensembl ENSG00000160255 ENSMUSG00000000290 UniProt P05107 P11835 RefSeq (mRNA) NM_000211 NM_001127491 NM_001303238 NM_008404 RefSeq (protein) NP_000202 NP_001120963 NP_001290167 NP_032430 Location (UCSC) Chr 21: 44.89 – 44.93 Mb Chr 10: 77.37 – 77.4 Mb PubMed search [3] [4]
Wikidata
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In molecular biology, CD18 (Integrin beta chain-2) is an integrin beta chain protein that is encoded by the ITGB2 gene in humans.^[5] Upon binding with one of a number of alpha chains, CD18 is capable of forming multiple heterodimers, which play significant roles in cellular adhesion and cell surface signaling, as well as important roles in immune responses.^[5][6] CD18 also exists in soluble, ligand binding forms. Deficiencies in CD18 expression can lead to adhesion defects in circulating white blood cells in humans, reducing the immune system's ability to fight off foreign invaders.