Interleukin 12

Search for
Structures	Swiss-model
Domains	InterPro

IL12A
IL12A
Identifiers
Symbol	IL12A
Alt. symbols	CLMF1, NKSF1, p35
NCBI gene	3592
HGNC	5969
OMIM	161560
RefSeq	NM_000882
UniProt	P29459
Other data
Locus	Chr. 3 p12-q13.2
Structures
Search for
Structures	Swiss-model
Domains	InterPro

Human Interleukin 12
Human Interleukin 12
	Crystal structure of human IL-12 (red helices)
Identifiers
Symbol	IL12, p70
PDB	1F45

interleukin 12B

Crystal structure of IL-12B

Identifiers

Symbol

IL12B

Alt. symbols

CLMF2, NKSF2, p40

Other data

Chr. 5 q31.1-33.1

Search for
Structures	Swiss-model
Domains	InterPro

Interleukin 12 (IL-12) is an interleukin that is naturally produced by dendritic cells,^[1] macrophages, neutrophils, helper T cells and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation. IL-12 belongs to the family of interleukin-12. IL-12 family is unique in comprising the only heterodimeric cytokines, which includes IL-12, IL-23, IL-27 and IL-35.^[2] Despite sharing many structural features and molecular partners, they mediate surprisingly diverse functional effects.

^ Kaliński P, Hilkens CM, Snijders A, Snijdewint FG, Kapsenberg ML (July 1997). "IL-12-deficient dendritic cells, generated in the presence of prostaglandin E2, promote type 2 cytokine production in maturing human naive T helper cells". Journal of Immunology. 159 (1): 28–35. doi:10.4049/jimmunol.159.1.28. PMID 9200435. S2CID 10617490.
^ Vignali DA, Kuchroo VK (July 2012). "IL-12 family cytokines: immunological playmakers". Nature Immunology. 13 (8): 722–8. doi:10.1038/ni.2366. PMC 4158817. PMID 22814351.

[1] Kaliński P, Hilkens CM, Snijders A, Snijdewint FG, Kapsenberg ML (July 1997). "IL-12-deficient dendritic cells, generated in the presence of prostaglandin E2, promote type 2 cytokine production in maturing human naive T helper cells". Journal of Immunology. 159 (1): 28–35. doi:10.4049/jimmunol.159.1.28. PMID 9200435. S2CID 10617490.

[2] Vignali DA, Kuchroo VK (July 2012). "IL-12 family cytokines: immunological playmakers". Nature Immunology. 13 (8): 722–8. doi:10.1038/ni.2366. PMC 4158817. PMID 22814351.

[1]

[2]