Intestinal permeability

Intestinal permeability is a term describing the control of material passing from inside the gastrointestinal tract through the cells lining the gut wall, into the rest of the body. The intestine normally exhibits some permeability, which allows nutrients to pass through the gut, while also maintaining a barrier function to keep potentially harmful substances (such as antigens) from leaving the intestine and migrating to the body more widely.^[1] In a healthy human intestine, small particles (< 4 Å in radius) can migrate through tight junction claudin pore pathways,^[2] and particles up to 10–15 Å (3.5 kDa) can transit through the paracellular space uptake route.^[3] There is some evidence abnormally increased intestinal permeability may play a role in some chronic diseases and inflammatory conditions.^[4] The most well understood condition with observed increased intestinal permeability is celiac disease.^[5]

^ M. Campieri; C. Fiocchi; S.B. Hanauer (31 March 2002). Inflammatory Bowel Disease: A Clinical Case Approach to Pathophysiology, Diagnosis, and Treatment. Springer. p. 7. ISBN 978-0-7923-8772-5.
^ Thoma YM, Anderson JM, Turner JR (2012). Johnson LR, et al. (eds.). Tight Junctions and the Intestinal Barrier. Vol. 1. Academic Press. pp. 1043–. ISBN 978-0-12-382027-3. {{cite book}}: |work= ignored (help)
^ Fasano, A. (February 2012). "Leaky Gut and Autoimmune Diseases". Clinical Reviews in Allergy & Immunology (Review). 42 (1): 71–78. doi:10.1007/s12016-011-8291-x. PMID 22109896. S2CID 4088994.
^ Cite error: The named reference Fasano was invoked but never defined (see the help page).
^ Cite error: The named reference LeonardSapone2017 was invoked but never defined (see the help page).

[CampieriFiocchi2002-1] M. Campieri; C. Fiocchi; S.B. Hanauer (31 March 2002). Inflammatory Bowel Disease: A Clinical Case Approach to Pathophysiology, Diagnosis, and Treatment. Springer. p. 7. ISBN 978-0-7923-8772-5.

[JohnsonGhishan2012-2] Thoma YM, Anderson JM, Turner JR (2012). Johnson LR, et al. (eds.). Tight Junctions and the Intestinal Barrier. Vol. 1. Academic Press. pp. 1043–. ISBN 978-0-12-382027-3. {{cite book}}: |work= ignored (help)

[leakygut2012-3] Fasano, A. (February 2012). "Leaky Gut and Autoimmune Diseases". Clinical Reviews in Allergy & Immunology (Review). 42 (1): 71–78. doi:10.1007/s12016-011-8291-x. PMID 22109896. S2CID 4088994.

[Fasano-4] Cite error: The named reference Fasano was invoked but never defined (see the help page).

[LeonardSapone2017-5] Cite error: The named reference LeonardSapone2017 was invoked but never defined (see the help page).

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