Intragenomic conflict

Intragenomic conflict refers to the evolutionary phenomenon where genes have phenotypic effects that promote their own transmission in detriment of the transmission of other genes that reside in the same genome.^[1]^[2]^[3]^[4] The selfish gene theory postulates that natural selection will increase the frequency of those genes whose phenotypic effects cause their transmission to new organisms, and most genes achieve this by cooperating with other genes in the same genome to build an organism capable of reproducing and/or helping kin to reproduce.^[5] The assumption of the prevalence of intragenomic cooperation underlies the organism-centered concept of inclusive fitness. However, conflict among genes in the same genome may arise both in events related to reproduction (a selfish gene may "cheat" and increase its own presence in gametes or offspring above the expected according to fair Mendelian segregation and fair gametogenesis) and altruism (genes in the same genome may disagree on how to value other organisms in the context of helping kin because coefficients of relatedness diverge between genes in the same genome).^[6]^[7]^[8]

^ Gardner, Andy; Úbeda, Francisco (6 November 2017). "The meaning of intragenomic conflict". Nature Ecology & Evolution. 1 (12): 1807–1815. doi:10.1038/s41559-017-0354-9. hdl:10023/13307. PMID 29109471. S2CID 3314539.
^ Austin., Burt (2006). Genes in conflict : the biology of selfish genetic elements. Trivers, Robert. Cambridge, MA: Belknap Press of Harvard University Press. ISBN 9780674027220. OCLC 647823687.
^ Spencer, Hamish G (2003). "Intragenomic Conflict". Encyclopedia of Life Sciences. John Wiley & Sons, Ltd. doi:10.1038/npg.els.0001714. ISBN 9780470015902. {{cite book}}: |work= ignored (help)
^ Hurst, Laurence D.; Atlan, Anne; Bengtsson, Bengt O. (September 1996). "Genetic Conflicts". The Quarterly Review of Biology. 71 (3): 317–364. doi:10.1086/419442. PMID 8828237. S2CID 24853836.
^ Dawkins, Richard (1976). The selfish gene. New York: Oxford University Press. ISBN 978-0198575191. OCLC 2681149.
^ Ågren, J. Arvid (December 2016). "Selfish genetic elements and the gene's-eye view of evolution". Current Zoology. 62 (6): 659–665. doi:10.1093/cz/zow102. PMC 5804262. PMID 29491953.
^ Werren, J. H. (20 June 2011). "Selfish genetic elements, genetic conflict, and evolutionary innovation". Proceedings of the National Academy of Sciences. 108 (Supplement_2): 10863–10870. Bibcode:2011PNAS..10810863W. doi:10.1073/pnas.1102343108. PMC 3131821. PMID 21690392.
^ Rice, William R. (23 November 2013). "Nothing in Genetics Makes Sense Except in Light of Genomic Conflict". Annual Review of Ecology, Evolution, and Systematics. 44 (1): 217–237. doi:10.1146/annurev-ecolsys-110411-160242.

[1] Gardner, Andy; Úbeda, Francisco (6 November 2017). "The meaning of intragenomic conflict". Nature Ecology & Evolution. 1 (12): 1807–1815. doi:10.1038/s41559-017-0354-9. hdl:10023/13307. PMID 29109471. S2CID 3314539.

[2] Austin., Burt (2006). Genes in conflict : the biology of selfish genetic elements. Trivers, Robert. Cambridge, MA: Belknap Press of Harvard University Press. ISBN 9780674027220. OCLC 647823687.

[3] Spencer, Hamish G (2003). "Intragenomic Conflict". Encyclopedia of Life Sciences. John Wiley & Sons, Ltd. doi:10.1038/npg.els.0001714. ISBN 9780470015902. {{cite book}}: |work= ignored (help)

[4] Hurst, Laurence D.; Atlan, Anne; Bengtsson, Bengt O. (September 1996). "Genetic Conflicts". The Quarterly Review of Biology. 71 (3): 317–364. doi:10.1086/419442. PMID 8828237. S2CID 24853836.

[5] Dawkins, Richard (1976). The selfish gene. New York: Oxford University Press. ISBN 978-0198575191. OCLC 2681149.

[6] Ågren, J. Arvid (December 2016). "Selfish genetic elements and the gene's-eye view of evolution". Current Zoology. 62 (6): 659–665. doi:10.1093/cz/zow102. PMC 5804262. PMID 29491953.

[7] Werren, J. H. (20 June 2011). "Selfish genetic elements, genetic conflict, and evolutionary innovation". Proceedings of the National Academy of Sciences. 108 (Supplement_2): 10863–10870. Bibcode:2011PNAS..10810863W. doi:10.1073/pnas.1102343108. PMC 3131821. PMID 21690392.

[8] Rice, William R. (23 November 2013). "Nothing in Genetics Makes Sense Except in Light of Genomic Conflict". Annual Review of Ecology, Evolution, and Systematics. 44 (1): 217–237. doi:10.1146/annurev-ecolsys-110411-160242.

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