Intravascular papillary endothelial hyperplasia

Intravascular papillary endothelial hyperplasia
Other names	Masson's hemangio-endotheliome vegetant intravasculaire, Masson's lesion, Masson's pseudoangiosarcoma, Masson's tumor, and papillary endothelial hyperplasia[1]
Micrograph of intravascular papillary endothelial hyperplasia. H&E stain.
Specialty	Oncology, rheumatology

Intravascular papillary endothelial hyperplasia (IPEH), also known as Masson's hemangio-endotheliome vegetant intravasculaire, Masson's lesion, Masson's pseudoangiosarcoma, Masson's tumor, and papillary endothelial hyperplasia, is a rare, benign tumor. It may mimic an angiosarcoma, with lesions that are red or purplish 5-mm to 5-cm papules and deep nodules on the head, neck, or upper extremities.^{[1][2]: 592}

The cause of intravascular papillary endothelial hyperplasia is unknown. Risk factors include a history of local trauma or prior vascular disorders.

Immunohistochemistry and histopathology are used to make the diagnosis of intravascular papillary endothelial hyperplasia. Differential diagnosis includes vascular malformation, angioma, pyogenic granuloma, angiosarcoma, epithelioid hemangioendothelioma, Kaposi’s sarcoma, and other more rare vascular tumors.

Three forms of intravascular papillary endothelial hyperplasia exist: the primary or pure form, the secondary or mixed form, and the extravascular form.

The treatment for intravascular papillary endothelial hyperplasia is complete surgical resection.