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Clinical data | |
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Trade names | Monoket, Imdur, others |
AHFS/Drugs.com | Monograph |
MedlinePlus | a682348 |
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Routes of administration | By mouth |
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Pharmacokinetic data | |
Bioavailability | >95% |
Protein binding | <5% |
Metabolism | Liver |
Elimination half-life | 5 hours |
Excretion | Kidney (93%) |
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ECHA InfoCard | 100.036.527 |
Chemical and physical data | |
Formula | C6H9NO6 |
Molar mass | 191.139 g·mol−1 |
3D model (JSmol) | |
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Isosorbide mononitrate, sold under many brand names, is a medication used for heart-related chest pain (angina), heart failure and esophageal spasms.[2] It can be used both to treat and to prevent heart-related chest pain; however, it is generally less preferred than beta blockers or calcium channel blockers.[2] It is taken by mouth.[2]
Common side effects include headache, low blood pressure with standing, blurry vision, and skin flushing.[2] Serious side effects may include low blood pressure especially if also exposed to PDE5 inhibitors such as sildenafil.[2] Use is not recommended in pregnancy.[3] It is believed to work by relaxing smooth muscle within blood vessels.[2]
It was patented in 1971 and approved for medical use in 1981.[4] It is available as a generic medication.[3] In 2021, isosorbide was the 111th most commonly prescribed medication in the United States, with more than 5 million prescriptions.[5][6]
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